Pak1ip1 PAK1 interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pak1ip1provided by RGD
Official Full Name: PAK1 interacting protein 1provided by RGD
Primary source: RGD:1565353
See related: EnsemblRapid:ENSRNOG00000015437 AllianceGenome:RGD:1565353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase inhibitor activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of signal transduction by p53 class mediator. Predicted to act upstream of or within cell population proliferation and roof of mouth development. Predicted to be active in nucleolus. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 81.2), Spleen (RPKM 77.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (23947978..23959055, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (23742217..23753325, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (21579987..21591064, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: p21-activated protein kinase-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037356.1 → NP_001032433.1 p21-activated protein kinase-interacting protein 1

See identical proteins and their annotated locations for NP_001032433.1

Status: PROVISIONAL

Source sequence(s)

BC107922

UniProtKB/TrEMBL

F7FPY4, Q32PZ0

Related

ENSRNOP00000061240.2, ENSRNOT00000066371.5

Conserved Domains (3) summary

COG2319
Location:37 → 274

WD40; WD40 repeat [General function prediction only]

sd00039
Location:45 → 80

7WD40; WD40 repeat [structural motif]

cl02567
Location:41 → 274

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...