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    Cep43 centrosomal protein 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep43provided by RGD
    Official Full Name
    centrosomal protein 43provided by RGD
    Primary source
    RGD:1583370
    See related
    EnsemblRapid:ENSRNOG00000055093 AllianceGenome:RGD:1583370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fgfr1op
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; positive regulation of cell growth; and positive regulation of cell migration. Predicted to be located in centriole; nucleus; and perinuclear region of cytoplasm. Predicted to be active in centrosome. Orthologous to human CEP43 (centrosomal protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.6), Spleen (RPKM 88.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep43 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (55080983..55111509, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52533418..52564025, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53122330..53152872, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482722 Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene uncharacterized LOC134484997 Neighboring gene uncharacterized LOC134484998 Neighboring gene ribonuclease T2 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene ribosomal protein S6 kinase A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FOP is a centriolar satellite protein involved in ciliogenesis. Lee JY, et al. PLoS One, 2013. PMID 23554904, Free PMC Article
    2. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. Mikolajka A, et al. J Mol Biol, 2006 Jun 16. PMID 16690081
    3. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Mano Y, et al. Cancer Sci, 2007 Dec. PMID 17888034, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein 43
    Names
    Fgfr1 oncogene partner

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101008.1 → NP_001094478.1  centrosomal protein 43

      See identical proteins and their annotated locations for NP_001094478.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098026
      UniProtKB/Swiss-Prot
      Q4V7C1
      UniProtKB/TrEMBL
      A0A8I6GIV0
      Related
      ENSRNOP00000104874.1, ENSRNOT00000163806.1
      Conserved Domains (1) summary
      pfam09398
      Location:54 → 134
      FOP_dimer; FOP N terminal dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      55080983..55111509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090788.2 → XP_038946716.1  centrosomal protein 43 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIV0
      Conserved Domains (1) summary
      pfam09398
      Location:54 → 134
      FOP_dimer; FOP N terminal dimerization domain

    2. XM_008758774.4 → XP_008756996.1  centrosomal protein 43 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIV0, A0A8L2R2K1
      Related
      ENSRNOP00000070312.2, ENSRNOT00000085501.3
      Conserved Domains (1) summary
      pfam09398
      Location:54 → 134
      FOP_dimer; FOP N terminal dimerization domain

    3. XM_039090781.2 → XP_038946709.1  centrosomal protein 43 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIV0
      Conserved Domains (1) summary
      pfam09398
      Location:54 → 134
      FOP_dimer; FOP N terminal dimerization domain

    4. XM_039090793.2 → XP_038946721.1  centrosomal protein 43 isoform X4

      Conserved Domains (1) summary
      pfam09398
      Location:54 → 134
      FOP_dimer; FOP N terminal dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7C1.1 GenPept UniProtKB/Swiss-Prot:Q4V7C1

    Gene LinkOut

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