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    Ntng2 netrin G2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntng2provided by RGD
    Official Full Name
    netrin G2provided by RGD
    Primary source
    RGD:1307089
    See related
    EnsemblRapid:ENSRNOG00000013694 AllianceGenome:RGD:1307089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including regulation of cell projection organization; regulation of presynapse assembly; and synapse organization. Predicted to be located in axon and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human NTNG2 (netrin G2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 38.6), Thymus (RPKM 35.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ntng2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32889856..32949032, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12492574..12551104, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7742511..7800834, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350345 Neighboring gene transcription termination factor 1 Neighboring gene senataxin Neighboring gene mediator complex subunit 27 Neighboring gene uncharacterized LOC134486065 Neighboring gene Rap guanine nucleotide exchange factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model. Pan Y, et al. Exp Neurol, 2010 Aug. PMID 20382146
    2. Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Nakashiba T, et al. Mech Dev, 2002 Feb. PMID 11804778
    3. Netrin-G/NGL complexes encode functional synaptic diversification. Matsukawa H, et al. J Neurosci, 2014 Nov 19. PMID 25411505, Free PMC Article
    4. NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Kim S, et al. Nat Neurosci, 2006 Oct. PMID 16980967
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic specialization assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    netrin-G2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107825.2 → NP_001101295.1  netrin-G2 isoform a precursor

      See identical proteins and their annotated locations for NP_001101295.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADT9, A6JTR1, A6JTR2, D4A9F4
      Related
      ENSRNOP00000045926.2, ENSRNOT00000045919.5
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:444 → 491
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:491 → 521
      EGF_2; EGF-like domain

    2. NM_001434226.1 → NP_001421155.1  netrin-G2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5J5, A0A8I6ADT9, A6JTR0, A6JTR2

    3. NM_001434227.1 → NP_001421156.1  netrin-G2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5J5, A0A8I6ADT9, A6JTR0, A6JTR2

    4. NM_001434228.1 → NP_001421157.1  netrin-G2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K5J5, A0A8I6ADT9, A6JTR0, A6JTR2

    RNA

    1. NR_197768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      32889856..32949032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591833.3 → XP_017447322.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    2. XM_017591829.3 → XP_017447318.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    3. XM_006233800.5 → XP_006233862.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    4. XM_039105225.2 → XP_038961153.1  netrin-G2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADT9, A6JTR2
      Related
      ENSRNOP00000110361.1, ENSRNOT00000168308.1
      Conserved Domains (3) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:490 → 537
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    5. XM_039105226.2 → XP_038961154.1  netrin-G2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADT9, A6JTR2
      Conserved Domains (3) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:456 → 503
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)

    6. XM_063283930.1 → XP_063140000.1  netrin-G2 isoform X5

    7. XM_063283929.1 → XP_063139999.1  netrin-G2 isoform X5

    8. XM_017591832.3 → XP_017447321.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Related
      ENSRNOP00000081677.1, ENSRNOT00000105485.2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    9. XM_063283933.1 → XP_063140003.1  netrin-G2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5J5, A0A8I6ADT9, A6JTR0, A6JTR2

    10. XM_017591831.3 → XP_017447320.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    11. XM_017591830.3 → XP_017447319.1  netrin-G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVI0, A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      cd00055
      Location:286 → 332
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:515 → 562
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:60 → 285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam07974
      Location:562 → 592
      EGF_2; EGF-like domain

    12. XM_063283932.1 → XP_063140002.1  netrin-G2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5J5, A0A8I6ADT9, A6JTR0, A6JTR2
      Related
      ENSRNOP00000073450.2, ENSRNOT00000082489.3

    13. XM_039105227.2 → XP_038961155.1  netrin-G2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      PHA03247
      Location:240 → 358
      PHA03247; large tegument protein UL36; Provisional
      cd00055
      Location:192 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:421 → 468
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:1 → 191
      Laminin_N; Laminin N-terminal (Domain VI)

    14. XM_039105228.2 → XP_038961156.1  netrin-G2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ADT9, A6JTR2
      Conserved Domains (4) summary
      PHA03247
      Location:240 → 358
      PHA03247; large tegument protein UL36; Provisional
      cd00055
      Location:192 → 238
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:421 → 468
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:1 → 191
      Laminin_N; Laminin N-terminal (Domain VI)
    Nucleotide Protein Strain
    Heading Accession and Version

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