Ppl periplakin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pplprovided by RGD
Official Full Name: periplakinprovided by RGD
Primary source: RGD:1305511
See related: EnsemblRapid:ENSRNOG00000002930 AllianceGenome:RGD:1305511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization; response to mechanical stimulus; and wound healing. Predicted to act upstream of or within regulation of antibacterial peptide production. Predicted to be located in plasma membrane. Predicted to be active in cornified envelope and cytoplasm. Predicted to colocalize with intermediate filament. Orthologous to human PPL (periplakin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 176.3), Kidney (RPKM 57.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (10957388..11003035)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (10450919..10496575)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (10644572..10690223)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail
Title: Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124545 (e-PCR)
- UniSTS:161367

Ppl (e-PCR), detects polymorphism
- UniSTS:144254

RH139799 (e-PCR)
- UniSTS:221883

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of antibacterial peptide production	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: periplakin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106976.1 → NP_001100446.1 periplakin

See identical proteins and their annotated locations for NP_001100446.1

Status: PROVISIONAL

Source sequence(s)

CH474017

UniProtKB/TrEMBL

A0A8I6A8D3, A6K4P2, D4A5T8

Related

ENSRNOP00000004026.4, ENSRNOT00000004026.6

Conserved Domains (4) summary

smart00250
Location:1655 → 1683

PLEC; Plectin repeat

TIGR02168
Location:871 → 1638

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:213 → 387

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl19219
Location:899 → 993

DUF342; Protein of unknown function (DUF342)