Mael maelstrom spermatogenic transposon silencer [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maelprovided by RGD
Official Full Name: maelstrom spermatogenic transposon silencerprovided by RGD
Primary source: RGD:1309333
See related: EnsemblRapid:ENSRNOG00000003790 AllianceGenome:RGD:1309333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309333
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in male meiotic nuclear division; negative regulation of macromolecule biosynthetic process; and spermatogenesis. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule biosynthetic process. Predicted to be located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and male germ cell nucleus. Predicted to be active in P granule and nucleus. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1561.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (80990040..81029623, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (78457073..78496657, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (84412569..84452140, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MAEL seems to function in nuage and non-nuage structures and interacts with MIWI.
Title: Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of developmental process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of reproductive process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of miRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	IEA Inferred from Electronic Annotation more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	ISO Inferred from Sequence Orthology more info
NOT located_in XY body	ISO Inferred from Sequence Orthology more info
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in autosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in piP-body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein maelstrom homolog

Names: maelstrom homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.