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    Btaf1 B-TFIID TATA-box binding protein associated factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 368042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btaf1provided by RGD
    Official Full Name
    B-TFIID TATA-box binding protein associated factor 1provided by RGD
    Primary source
    RGD:1564130
    See related
    EnsemblRapid:ENSRNOG00000017938 AllianceGenome:RGD:1564130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564130
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and transcription coregulator activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Orthologous to human BTAF1 (B-TFIID TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 169.4), Testes (RPKM 163.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btaf1 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (244065728..244156457)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234653219..234743903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255564247..255654932)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100026 Neighboring gene ribosomal protein S27a, pseudogene 28 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene membrane associated ring-CH-type finger 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. Chicca JJ 2nd, et al. Mol Cell Biol, 1998 Mar. PMID 9488487, Free PMC Article
    2. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Fugger K, et al. Nat Commun, 2013. PMID 23361013
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TATA-binding protein-associated factor 172
    Names
    BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, (Mot1 homolog, S. cerevisiae)
    BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191917.1 → NP_001178846.1  TATA-binding protein-associated factor 172

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K1N4
      Related
      ENSRNOP00000024465.8, ENSRNOT00000024465.8
      Conserved Domains (6) summary
      cd00046
      Location:1292 → 1441
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1275 → 1591
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1650 → 1750
      Helicase_C; Helicase conserved C-terminal domain
      pfam12054
      Location:592 → 1057
      DUF3535; Domain of unknown function (DUF3535)
      pfam13513
      Location:409 → 460
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:358 → 383
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      244065728..244156457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231332.5 → XP_006231394.1  TATA-binding protein-associated factor 172 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1N4, A0A8I5ZQD2
      Related
      ENSRNOP00000080583.1, ENSRNOT00000113933.2
      Conserved Domains (6) summary
      cd00046
      Location:1285 → 1434
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:1268 → 1584
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1643 → 1743
      Helicase_C; Helicase conserved C-terminal domain
      pfam12054
      Location:585 → 1050
      DUF3535; Domain of unknown function (DUF3535)
      pfam13513
      Location:402 → 453
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:351 → 376
      HEAT; HEAT repeat [structural motif]

    2. XM_039085850.2 → XP_038941778.1  TATA-binding protein-associated factor 172 isoform X2

      Conserved Domains (4) summary
      COG0553
      Location:456 → 1028
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      sd00044
      Location:335 → 363
      HEAT; HEAT repeat [structural motif]
      cd17999
      Location:493 → 730
      DEXHc_Mot1; DEXH-box helicase domain of Mot1
      pfam12054
      Location:1 → 278
      DUF3535; Domain of unknown function (DUF3535)
    Nucleotide Protein Strain
    Heading Accession and Version

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