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    Slc22a12 solute carrier family 22 member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc22a12provided by RGD
    Official Full Name
    solute carrier family 22 member 12provided by RGD
    Primary source
    RGD:621628
    See related
    EnsemblRapid:ENSRNOG00000021108 AllianceGenome:RGD:621628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rst; URAT1; Slc22al2
    Summary
    Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to insulin stimulus; renal urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 740.6) See more
    Orthologs
    human all
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    Genomic context

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    See Slc22a12 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213274266..213282793, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203845039..203852496, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221910787..221919277, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097407 Neighboring gene RAS guanyl releasing protein 2 Neighboring gene neurexin 2 Neighboring gene PRELI domain containing 1, pseudogene 5 Neighboring gene ribosomal protein S6 kinase A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats. Lee CT, et al. Mol Nutr Food Res, 2017 Oct. PMID 28499081
    2. Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy. Wu X, et al. J Physiol Biochem, 2015 Jun. PMID 25773064
    3. Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Sato M, et al. Biochim Biophys Acta, 2011 Jun. PMID 21074513
    4. Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. Wakida N, et al. J Clin Endocrinol Metab, 2005 Apr. PMID 15634722
    5. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. Toyoki D, et al. Am J Physiol Renal Physiol, 2017 Sep 1. PMID 28679589

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
      Title: Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
    2. Resveratrol reduced URAT1 mRNA expression under high uric acid levels, thereby reducing uric acid reabsorption in renal cells.
      Title: Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats.
    3. Insulin significantly increased URAT1 and decreased ABCG2 levels, resulting in increased kidney tubule uric acid reabsorption in streptozotocin-diabetic rats.
      Title: Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2.
    4. URAT1 lysosome degradation is affected by uric acid in uric acid nephropathy.
      Title: Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.
    5. Data show that Urat1 (Slc22a12) is involved in uric acid reabsorption in rats in the same manner as URAT1 in humans, suggesting a useful model to study issues related to the role of human URAT1.
      Title: Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124974

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal urate salt excretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 12
    Names
    solute carrier family 22 (organic anion/cation transporter), member 12
    solute carrier family 22 (organic anion/urate transporter), member 12
    solute carrier family 22 (organic cation transporter)-like 2
    urate anion exchanger 1
    urate:anion antiporter SLC22A12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034943.1 → NP_001030115.1  solute carrier family 22 member 12

      See identical proteins and their annotated locations for NP_001030115.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103638
      UniProtKB/Swiss-Prot
      Q3ZAV1
      UniProtKB/TrEMBL
      A6HZI0
      Related
      ENSRNOP00000075925.1, ENSRNOT00000092270.3
      Conserved Domains (1) summary
      cd17374
      Location:109 → 516
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213274266..213282793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269883.1 → XP_063125953.1  solute carrier family 22 member 12 isoform X5

    2. XM_063269880.1 → XP_063125950.1  solute carrier family 22 member 12 isoform X3

      UniProtKB/TrEMBL
      A6HZI0

    3. XM_063269882.1 → XP_063125952.1  solute carrier family 22 member 12 isoform X4

    4. XM_063269878.1 → XP_063125948.1  solute carrier family 22 member 12 isoform X2

    5. XM_039085569.1 → XP_038941497.1  solute carrier family 22 member 12 isoform X1

      UniProtKB/TrEMBL
      A6HZI0
      Conserved Domains (1) summary
      cd17374
      Location:109 → 541
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZAV1.1 GenPept UniProtKB/Swiss-Prot:Q3ZAV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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