Foxp2 forkhead box P2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxp2provided by RGD
Official Full Name: forkhead box P2provided by RGD
Primary source: RGD:1559697
See related: EnsemblRapid:ENSRNOG00000054508 AllianceGenome:RGD:1559697
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559697
Summary: Enables nuclear androgen receptor binding activity. Involved in forebrain development; innate vocalization behavior; and response to testosterone. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 33.7), Brain (RPKM 26.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (44099848..44677700)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (43133827..43712442)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (41364441..41944685)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H1 Receptors.
Title: Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H(1) Receptors.
LncRNA TTN-AS1 exacerbates extracellular matrix accumulation via miR-493-3p/FOXP2 axis in diabetic nephropathy.
Title: LncRNA TTN-AS1 exacerbates extracellular matrix accumulation via miR-493-3p/FOXP2 axis in diabetic nephropathy.
lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis.
Title: lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis.
The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD.
Title: miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model.
The results of this study showed that FOXP2 expression in respiratory brainstem areas selectively delineates laryngeal and hypoglossal pre-motor neuron populations.
Title: Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas.
Androgen effects on both Foxp2 and Foxp1 were found to occur in the striatum, cerebellar vermis, and cortex.
Title: Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization.
Foxp2 is implicated as a component of the neurobiological basis of sex differences in mammalian vocal communication.
Title: Foxp2 mediates sex differences in ultrasonic vocalization by rat pups and directs order of maternal retrieval.
two groups of dorsolateral pontine neurons express a common marker gene, the constitutively-expressed transcription factor Forkhead box protein 2
Title: FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation.
observed a sex difference in the intensity of Foxp2 immunoreactivity in the Purkinje cell layer of the cerebellum, with male rats exhibiting greater immunolabeling than female rats; data suggest a sex difference in Foxp2 expression in the cerebellum
Title: Analysis of Foxp2 expression in the cerebellum reveals a possible sex difference.
Data show that direct interaction between Foxp2 and Nkx2.1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C during transition of AT2 cells to an AT1 cell phenotype.
Title: Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN102213 (e-PCR)
- UniSTS:427010

REN102214 (e-PCR)
- UniSTS:427011

REN103238 (e-PCR)
- UniSTS:428035

REN102215 (e-PCR)
- UniSTS:427012

REN103240 (e-PCR)
- UniSTS:428037

REN102218 (e-PCR)
- UniSTS:427015

REN102219 (e-PCR)
- UniSTS:427016

ECD06693 (e-PCR)
- UniSTS:287753

ECD03612 (e-PCR)
- UniSTS:284692

REN103256 (e-PCR)
- UniSTS:428053

REN102239 (e-PCR)
- UniSTS:427036

REN103265 (e-PCR)
- UniSTS:428062

REN103266 (e-PCR)
- UniSTS:428063

ECD01298 (e-PCR)
- UniSTS:282404

REN102256 (e-PCR)
- UniSTS:427053

ECD02857 (e-PCR)
- UniSTS:283950

REN103285 (e-PCR)
- UniSTS:428082

REN103286 (e-PCR)
- UniSTS:428083

REN102277 (e-PCR)
- UniSTS:427074

REN102278 (e-PCR)
- UniSTS:427075

stSG611484 (e-PCR)
- UniSTS:449876

MARC_13931-13932:1007579490:1 (e-PCR)
- UniSTS:267613

MARC_13931-13932:1025532946:1 (e-PCR)
- UniSTS:267613

stSG611494 (e-PCR)
- UniSTS:449886

stSG611518 (e-PCR)
- UniSTS:449909

REN102585 (e-PCR)
- UniSTS:427382

stSG611519 (e-PCR)
- UniSTS:449910

stSG611520 (e-PCR)
- UniSTS:449911

ECD00361 (e-PCR)
- UniSTS:281472

REN103118 (e-PCR)
- UniSTS:427915

AU048259 (e-PCR)
- UniSTS:109713

REN102875 (e-PCR)
- UniSTS:427672

REN101856 (e-PCR)
- UniSTS:426653

REN101860 (e-PCR)
- UniSTS:426657

REN103408 (e-PCR)
- UniSTS:428205

REN103156 (e-PCR)
- UniSTS:427953

REN103413 (e-PCR)
- UniSTS:428210

REN103414 (e-PCR)
- UniSTS:428211

REN103422 (e-PCR)
- UniSTS:428219

REN103423 (e-PCR)
- UniSTS:428220

REN103424 (e-PCR)
- UniSTS:428221

REN103425 (e-PCR)
- UniSTS:428222

REN103427 (e-PCR)
- UniSTS:428224

REN103428 (e-PCR)
- UniSTS:428225

REN103431 (e-PCR)
- UniSTS:428228

REN103433 (e-PCR)
- UniSTS:428230

BF402867 (e-PCR)
- UniSTS:245958

ECD00202 (e-PCR)
- UniSTS:281316

ECD04080 (e-PCR)
- UniSTS:285159

REN102194 (e-PCR)
- UniSTS:426991

ECD04612 (e-PCR)
- UniSTS:285684

REN102201 (e-PCR)
- UniSTS:426998

REN102202 (e-PCR)
- UniSTS:426999

BE110309 (e-PCR)
- UniSTS:245239

REN102203 (e-PCR)
- UniSTS:427000

REN102204 (e-PCR)
- UniSTS:427001

REN102208 (e-PCR)
- UniSTS:427005

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in caudate nucleus development	IEA Inferred from Electronic Annotation more info
involved_in caudate nucleus development	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in innate vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in putamen development	IEA Inferred from Electronic Annotation more info
involved_in putamen development	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein P2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271104.1 → NP_001258033.1 forkhead box protein P2

See identical proteins and their annotated locations for NP_001258033.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P0CF24

UniProtKB/TrEMBL

A0A8I6AF22

Conserved Domains (2) summary

cd00059
Location:499 → 571

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:337 → 404

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

44099848..44677700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286479.1 → XP_063142549.1 forkhead box protein P2 isoform X5

UniProtKB/TrEMBL

A0A8I6AF22

Related

ENSRNOP00000091158.2, ENSRNOT00000111171.2
XM_008762718.4 → XP_008760940.1 forkhead box protein P2 isoform X1

See identical proteins and their annotated locations for XP_008760940.1

UniProtKB/TrEMBL

A0A8I6AF22, A0A8L2R296, A6IE10

Related

ENSRNOP00000069190.3, ENSRNOT00000087146.3

Conserved Domains (2) summary

cd00059
Location:500 → 572

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:338 → 405

FOXP-CC; FOXP coiled-coil domain
XM_063286477.1 → XP_063142547.1 forkhead box protein P2 isoform X3

UniProtKB/TrEMBL

A0A8I6AF22
XM_039108099.2 → XP_038964027.1 forkhead box protein P2 isoform X4

UniProtKB/TrEMBL

A0A8I6AF22

Related

ENSRNOP00000103473.1, ENSRNOT00000147682.1

Conserved Domains (3) summary

COG5025
Location:473 → 658

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:338 → 405

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:499 → 580

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
XM_002729285.7 → XP_002729331.1 forkhead box protein P2 isoform X1

See identical proteins and their annotated locations for XP_002729331.1

UniProtKB/TrEMBL

A0A8I6AF22, A0A8L2R296, A6IE10

Conserved Domains (2) summary

cd00059
Location:500 → 572

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:338 → 405

FOXP-CC; FOXP coiled-coil domain
XM_063286476.1 → XP_063142546.1 forkhead box protein P2 isoform X2

UniProtKB/Swiss-Prot

P0CF24

UniProtKB/TrEMBL

A0A8I6AF22
XM_063286478.1 → XP_063142548.1 forkhead box protein P2 isoform X3

UniProtKB/TrEMBL

A0A8I6AF22
XM_006236115.5 → XP_006236177.1 forkhead box protein P2 isoform X1

See identical proteins and their annotated locations for XP_006236177.1

UniProtKB/TrEMBL

A0A8I6AF22, A0A8L2R296, A6IE10

Conserved Domains (2) summary

cd00059
Location:500 → 572

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:338 → 405

FOXP-CC; FOXP coiled-coil domain