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    Ikzf3 IKAROS family zinc finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ikzf3provided by RGD
    Official Full Name
    IKAROS family zinc finger 3provided by RGD
    Primary source
    RGD:1307024
    See related
    EnsemblRapid:ENSRNOG00000007200 AllianceGenome:RGD:1307024
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfpn1a3
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Predicted to be involved in several processes, including lymphocyte differentiation; positive regulation of transcription by RNA polymerase II; and regulation of B cell activation. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 219.9), Spleen (RPKM 151.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ikzf3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83956850..84049861, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83460564..83553591, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86420757..86509454, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480865 Neighboring gene U6 spliceosomal RNA Neighboring gene zona pellucida binding protein 2 Neighboring gene ORMDL sphingolipid biosynthesis regulator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells. Li X, et al. Cancer Cell, 2014 May 12. PMID 24823637, Free PMC Article
    2. Aiolos regulates B cell activation and maturation to effector state. Wang JH, et al. Immunity, 1998 Oct. PMID 9806640
    3. Combinatorial effects of splice variants modulate function of Aiolos. Caballero R, et al. J Cell Sci, 2007 Aug 1. PMID 17646674
    4. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. Romero F, et al. EMBO J, 1999 Jun 15. PMID 10369681, Free PMC Article
    5. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. Morgan B, et al. EMBO J, 1997 Apr 15. PMID 9155026, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Aiolos
    Names
    zinc finger protein, subfamily 1A, 3 (Aiolos)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107047.1 → NP_001100517.1  zinc finger protein Aiolos

      See identical proteins and their annotated locations for NP_001100517.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6GAR3, A6HIT0, D3ZSW3
      Related
      ENSRNOP00000009454.4, ENSRNOT00000009454.7
      Conserved Domains (3) summary
      COG5048
      Location:107 → 219
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:133 → 157
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83956850..84049861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768049.4 → XP_008766271.1  zinc finger protein Aiolos isoform X1

      See identical proteins and their annotated locations for XP_008766271.1

      UniProtKB/TrEMBL
      A6HIS9
    Nucleotide Protein Strain
    Heading Accession and Version

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