Serpinb10 serpin family B member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb10provided by RGD
Official Full Name: serpin family B member 10provided by RGD
Primary source: RGD:628853
See related: EnsemblRapid:ENSRNOG00000002417 AllianceGenome:RGD:628853
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trespin
Summary: Enables peptidase inhibitor activity. Involved in negative regulation of proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in extracellular space. Orthologous to human SERPINB10 (serpin family B member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 98.3), Spleen (RPKM 52.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (24067971..24085814)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (23553348..23571182)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (27466036..27483789)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trespin decreases after differentiation of NRP-152 cells to a luminal variant, suggesting Trespin is specific for basal prostatic epithelial cells. Trespin is up-regulated by dexamethasone and IGF-I.
Title: Regulation of trespin expression by modulators of cell growth, differentiation, and apoptosis in prostatic epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serpin B10

Names: TGF-beta-repressible serine proteinase inhibitor; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10; serpin peptidase inhibitor, clade B (ovalbumin), member 10; transforming growth factor beta repressible serpin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153733.2 → NP_714955.2 serpin B10

See identical proteins and their annotated locations for NP_714955.2

Status: PROVISIONAL

Source sequence(s)

BC061735

UniProtKB/TrEMBL

A6JSW0, G3V6B2

Related

ENSRNOP00000003314.3, ENSRNOT00000003314.7

Conserved Domains (1) summary

cd19569
Location:1 → 397

serpinB10_bomapin; serpin family B member 10, bomapin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

24067971..24085814

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090410.2 → XP_038946338.1 serpin B10 isoform X1

Conserved Domains (1) summary

cl38926
Location:1 → 265

serpin; SERine Proteinase INhibitors (serpin) family