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    Erc2 ELKS/RAB6-interacting/CAST family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Erc2provided by RGD
    Official Full Name
    ELKS/RAB6-interacting/CAST family member 2provided by RGD
    Primary source
    RGD:708372
    See related
    EnsemblRapid:ENSRNOG00000015148 AllianceGenome:RGD:708372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAST; Cmbp
    Summary
    Enables PDZ domain binding activity. Involved in synapse organization. Located in several cellular components, including distal axon; presynaptic active zone; and presynaptic membrane. Part of protein-containing complex. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC2 (ELKS/RAB6-interacting/CAST family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 287.7), Liver (RPKM 22.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Erc2 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2819399..3680258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2812712..3673624)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3258580..4283592)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ATP synthase c subunit lysine N-methyltransferase, pseudogene 1 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12 Neighboring gene uncharacterized LOC108348452 Neighboring gene PRAME family member 12 pseudogene Neighboring gene aconitase 2, pseudogene 1 Neighboring gene uncharacterized LOC134482442 Neighboring gene cyclin-dependent kinases regulatory subunit 2-like Neighboring gene uncharacterized LOC120097388 Neighboring gene uncharacterized LOC103693876 Neighboring gene Wnt family member 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Kaeser PS, et al. Neuron, 2009 Oct 29. PMID 19874790, Free PMC Article
    2. Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1. Ko J, et al. J Neurosci, 2006 Jan 18. PMID 16421316, Free PMC Article
    3. Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis. Guo HX, et al. Int J Mol Sci, 2022 Dec 7. PMID 36555116, Free PMC Article
    4. Formation of Golgi-derived active zone precursor vesicles. Maas C, et al. J Neurosci, 2012 Aug 8. PMID 22875941, Free PMC Article
    5. CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. Deguchi-Tawarada M, et al. Genes Cells, 2004 Jan. PMID 14723704

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.
      Title: Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.
    2. ERC2 promotes presynaptic syntenin-1 clustering by two distinct mechanisms
      Title: Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1.
    3. RIM1- or Bassoon-binding region of CAST impairs synaptic transmission in cultured superior cervical ganglion neurons
      Title: Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.
    4. characterized a family of active zone proteins whose binding to RIMs, presynaptic active zone proteins that regulate neurotransmitter release, is regulated by tissue-specific alternative splicing
      Title: A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.
    5. The interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones.
      Title: Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables PDZ domain binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ERC protein 2
    Names
    CAST1
    CAZ-associated structural protein 1
    cytomatrix protein p110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401498.1 → NP_001388427.1  ERC protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q8CIZ0, Q8K3M6

    2. NM_170787.3 → NP_740768.1  ERC protein 2 isoform 2

      See identical proteins and their annotated locations for NP_740768.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZMM4, Z4YNN0
      Related
      ENSRNOP00000102790.1, ENSRNOT00000155794.1
      Conserved Domains (2) summary
      pfam01496
      Location:398 → 482
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam10174
      Location:151 → 875
      Cast; RIM-binding protein of the cytomatrix active zone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      2819399..3680258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275106.1 → XP_063131176.1  ERC protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6API8

    2. XM_063275108.1 → XP_063131178.1  ERC protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6API8

    3. XM_063275105.1 → XP_063131175.1  ERC protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6API8

    4. XM_039094229.1 → XP_038950157.1  ERC protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6API8
      Conserved Domains (1) summary
      pfam10174
      Location:151 → 920
      Cast; RIM-binding protein of the cytomatrix active zone

    5. XM_039094232.1 → XP_038950160.1  ERC protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6API8
      Conserved Domains (1) summary
      pfam10174
      Location:151 → 908
      Cast; RIM-binding protein of the cytomatrix active zone

    6. XM_063275111.1 → XP_063131181.1  ERC protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6API8

    7. XM_063275110.1 → XP_063131180.1  ERC protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6API8

    8. XM_063275114.1 → XP_063131184.1  ERC protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6API8

    9. XM_063275116.1 → XP_063131186.1  ERC protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6API8

    10. XM_063275109.1 → XP_063131179.1  ERC protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6API8

    11. XM_039094233.2 → XP_038950161.1  ERC protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6API8
      Related
      ENSRNOP00000099484.1, ENSRNOT00000163642.1
      Conserved Domains (1) summary
      pfam10174
      Location:151 → 900
      Cast; RIM-binding protein of the cytomatrix active zone

    12. XM_063275119.1 → XP_063131189.1  ERC protein 2 isoform X10

      UniProtKB/TrEMBL
      D3ZMM4

    13. XM_063275120.1 → XP_063131190.1  ERC protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K140
      Related
      ENSRNOP00000020427.8, ENSRNOT00000020427.8

    14. XM_063275115.1 → XP_063131185.1  ERC protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6API8

    15. XM_039094235.1 → XP_038950163.1  ERC protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6API8
      Conserved Domains (1) summary
      pfam10174
      Location:151 → 914
      Cast; RIM-binding protein of the cytomatrix active zone

    16. XM_063275117.1 → XP_063131187.1  ERC protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6API8

    17. XM_063275118.1 → XP_063131188.1  ERC protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6API8

    18. XM_017600007.2 → XP_017455496.2  ERC protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6API8
      Conserved Domains (1) summary
      pfam10174
      Location:151 → 907
      Cast; RIM-binding protein of the cytomatrix active zone

    19. XM_063275121.1 → XP_063131191.1  ERC protein 2 isoform X12

      UniProtKB/TrEMBL
      D3ZMM4
      Related
      ENSRNOP00000096580.2, ENSRNOT00000107815.2

    20. XM_063275123.1 → XP_063131193.1  ERC protein 2 isoform X14

      UniProtKB/TrEMBL
      A6KML3

    21. XM_063275113.1 → XP_063131183.1  ERC protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6API8

    22. XM_063275107.1 → XP_063131177.1  ERC protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6API8

    23. XM_063275112.1 → XP_063131182.1  ERC protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6API8

    24. XM_063275122.1 → XP_063131192.1  ERC protein 2 isoform X13

    RNA

    1. XR_010058279.1 RNA Sequence

    2. XR_010058280.1 RNA Sequence

    3. XR_010058281.1 RNA Sequence

    4. XR_010058282.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3M6.1 GenPept UniProtKB/Swiss-Prot:Q8K3M6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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