Ubl4a ubiquitin-like 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubl4aprovided by RGD
Official Full Name: ubiquitin-like 4Aprovided by RGD
Primary source: RGD:1563983
See related: EnsemblRapid:ENSRNOG00000053061 AllianceGenome:RGD:1563983
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ubl4; RGD1563983
Summary: Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in establishment of protein localization to membrane; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of BAT3 complex. Orthologous to human UBL4A (ubiquitin like 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 243.5), Heart (RPKM 221.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157302528..157305380, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152151242..152154094, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156340919..156343771)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc10a3 (e-PCR), detects polymorphism
- UniSTS:527538

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BAT3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BAT3 complex	IEA Inferred from Electronic Annotation more info
part_of BAT3 complex	ISO Inferred from Sequence Orthology more info
part_of BAT3 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-like protein 4A

Names: ubiquitin-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106346.2 → NP_001099816.1 ubiquitin-like protein 4A

See identical proteins and their annotated locations for NP_001099816.1

Status: PROVISIONAL

Source sequence(s)

BC166513

UniProtKB/Swiss-Prot

B2GV38

UniProtKB/TrEMBL

A0A8L2URF4

Related

ENSRNOP00000074769.2, ENSRNOT00000091810.3

Conserved Domains (2) summary

cd01807
Location:1 → 72

Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins

pfam17840
Location:96 → 142

Tugs; Tethering Ubl4a to BAGS domain