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    Cdc42bpa CDC42 binding protein kinase alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc42bpaprovided by RGD
    Official Full Name
    CDC42 binding protein kinase alphaprovided by RGD
    Primary source
    RGD:621406
    See related
    EnsemblRapid:ENSRNOG00000002841 AllianceGenome:RGD:621406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrck; Pk428
    Summary
    Enables several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including actomyosin structure organization; protein phosphorylation; and regulation of small GTPase mediated signal transduction. Located in actomyosin; cell leading edge; and cell-cell junction. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 292.6), Lung (RPKM 199.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc42bpa in Genome Data Viewer
    Location:
    13q26
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94215359..94435681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91683775..91903732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98231326..98447762)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene uncharacterized LOC134481630 Neighboring gene coenzyme Q8A Neighboring gene presenilin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. Zhao Y, et al. J Biol Chem, 1997 Apr 11. PMID 9092543
    2. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Tan I, et al. Mol Cell Biol, 2001 Apr. PMID 11283256, Free PMC Article
    3. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. Tan I, et al. J Biol Chem, 2001 Jun 15. PMID 11399775
    4. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. Tan I, et al. FEBS Lett, 2011 May 6. PMID 21457715
    5. Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Gomes ER, et al. Cell, 2005 May 6. PMID 15882626

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities.
      Title: Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
    2. Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network.
      Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.
    3. FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42.
      Title: Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actomyosin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK alpha
    Names
    MRCK alpha
    Ser-Thr protein kinase related to the myotonic dystrophy protein kinase
    myotonic dystrophy kinase-related CDC42-binding kinase alpha
    myotonic dystrophy protein kinase-like alpha
    mytonic dystrophy kinase-related Cdc42-binding kinase
    NP_446109.2
    XP_038946163.1
    XP_038946165.1
    XP_038946170.1
    XP_038946173.1
    XP_038946174.1
    XP_038946175.1
    XP_038946179.1
    XP_038946184.1
    XP_038946185.1
    XP_038946187.1
    XP_038946189.1
    XP_038946190.1
    XP_038946192.1
    XP_038946194.1
    XP_063128026.1
    XP_063128027.1
    XP_063128028.1
    XP_063128029.1
    XP_063128030.1
    XP_063128031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053657.2 → NP_446109.2  serine/threonine-protein kinase MRCK alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A6JGG0, G3V6C9
      Related
      ENSRNOP00000003837.2, ENSRNOT00000003837.5
      Conserved Domains (6) summary
      COG0419
      Location:442 → 969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1072 → 1206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1232 → 1496
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1011 → 1070
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      94215359..94435681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090235.2 → XP_038946163.1  serine/threonine-protein kinase MRCK alpha isoform X1

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1123 → 1257
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1283 → 1547
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1062 → 1121
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_039090251.2 → XP_038946179.1  serine/threonine-protein kinase MRCK alpha isoform X8

      UniProtKB/Swiss-Prot
      O54874
      Related
      ENSRNOP00000099199.1, ENSRNOT00000151561.1
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1059 → 1193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1219 → 1483
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:998 → 1057
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_039090262.2 → XP_038946190.1  serine/threonine-protein kinase MRCK alpha isoform X16

      UniProtKB/TrEMBL
      A0A8I6G3L7
      Conserved Domains (6) summary
      pfam08826
      Location:800 → 860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442 → 860
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:978 → 1112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1138 → 1402
      CNH; CNH domain
      cl00040
      Location:917 → 976
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_063271959.1 → XP_063128029.1  serine/threonine-protein kinase MRCK alpha isoform X14

      UniProtKB/TrEMBL
      A0A8I6G3L7

    5. XM_063271956.1 → XP_063128026.1  serine/threonine-protein kinase MRCK alpha isoform X7

      UniProtKB/Swiss-Prot
      O54874

    6. XM_039090242.2 → XP_038946170.1  serine/threonine-protein kinase MRCK alpha isoform X3

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1248 → 1512
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1027 → 1086
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    7. XM_039090257.2 → XP_038946185.1  serine/threonine-protein kinase MRCK alpha isoform X11

      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A0A8I6AWL9
      Related
      ENSRNOP00000093143.1, ENSRNOT00000102712.2
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1248 → 1512
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1027 → 1086
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    8. XM_039090245.2 → XP_038946173.1  serine/threonine-protein kinase MRCK alpha isoform X4

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1075 → 1209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1235 → 1499
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1014 → 1073
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    9. XM_039090259.2 → XP_038946187.1  serine/threonine-protein kinase MRCK alpha isoform X13

      UniProtKB/Swiss-Prot
      O54874
      Related
      ENSRNOP00000077481.2, ENSRNOT00000116713.2
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1075 → 1209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1235 → 1499
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1014 → 1073
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    10. XM_039090237.2 → XP_038946165.1  serine/threonine-protein kinase MRCK alpha isoform X2

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1107 → 1241
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1267 → 1531
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1046 → 1105
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    11. XM_039090247.2 → XP_038946175.1  serine/threonine-protein kinase MRCK alpha isoform X6

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1072 → 1206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1232 → 1496
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1011 → 1070
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    12. XM_039090261.2 → XP_038946189.1  serine/threonine-protein kinase MRCK alpha isoform X15

      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A0A8I5Y183
      Related
      ENSRNOP00000086891.1, ENSRNOT00000109203.2
      Conserved Domains (6) summary
      COG0419
      Location:442 → 958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1059 → 1193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1219 → 1483
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:998 → 1057
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    13. XM_039090246.2 → XP_038946174.1  serine/threonine-protein kinase MRCK alpha isoform X5

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442 → 944
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1074 → 1208
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1234 → 1498
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:1013 → 1072
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    14. XM_039090256.2 → XP_038946184.1  serine/threonine-protein kinase MRCK alpha isoform X10

      UniProtKB/TrEMBL
      A0A8I6A4M2
      Conserved Domains (6) summary
      COG0419
      Location:442 → 949
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1039 → 1173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1199 → 1463
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:978 → 1037
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    15. XM_039090264.2 → XP_038946192.1  serine/threonine-protein kinase MRCK alpha isoform X17

      UniProtKB/TrEMBL
      A0A8I6A4M2
      Related
      ENSRNOP00000103002.1, ENSRNOT00000151394.1
      Conserved Domains (6) summary
      COG0419
      Location:442 → 949
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1039 → 1173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1199 → 1463
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:978 → 1037
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    16. XM_063271957.1 → XP_063128027.1  serine/threonine-protein kinase MRCK alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6G3L7

    17. XM_039090266.2 → XP_038946194.1  serine/threonine-protein kinase MRCK alpha isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZRP1, A0A8I6G3L7
      Related
      ENSRNOP00000081450.2, ENSRNOT00000105577.2
      Conserved Domains (6) summary
      pfam08826
      Location:800 → 860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442 → 860
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:978 → 1112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1138 → 1402
      CNH; CNH domain
      cl00040
      Location:917 → 976
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    18. XM_063271960.1 → XP_063128030.1  serine/threonine-protein kinase MRCK alpha isoform X18

      UniProtKB/TrEMBL
      A0A8I6G3L7

    19. XM_063271961.1 → XP_063128031.1  serine/threonine-protein kinase MRCK alpha isoform X19

      UniProtKB/TrEMBL
      A6JGG1

    20. XM_063271958.1 → XP_063128028.1  serine/threonine-protein kinase MRCK alpha isoform X12

      UniProtKB/TrEMBL
      A0A0G2K5Z1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54874.1 GenPept UniProtKB/Swiss-Prot:O54874

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