Nfs1 NFS1 cysteine desulfurase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfs1provided by RGD
Official Full Name: NFS1 cysteine desulfuraseprovided by RGD
Primary source: RGD:620912
See related: EnsemblRapid:ENSRNOG00000045686 AllianceGenome:RGD:620912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nifs
Summary: Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Predicted to be involved in iron-sulfur cluster assembly and molybdopterin cofactor metabolic process. Predicted to be located in centrosome; mitochondrial matrix; and nucleoplasm. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 52. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1331.1), Adrenal (RPKM 391.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165097390..165119730, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144637309..144659660, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151665813..151688151, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139369 (e-PCR)
- UniSTS:221455

RH128176 (e-PCR)
- UniSTS:211484

D3Rat237 (e-PCR), detects polymorphism
- UniSTS:227622

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine desulfurase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine desulfurase activity	IEA Inferred from Electronic Annotation more info
enables cysteine desulfurase activity	ISO Inferred from Sequence Orthology more info
enables cysteine desulfurase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in [2Fe-2S] cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in [2Fe-2S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in [2Fe-2S] cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in [4Fe-4S] cluster assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of [4Fe-4S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in [4Fe-4S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in [4Fe-4S] cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron incorporation into metallo-sulfur cluster	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in molybdopterin cofactor metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial [2Fe-2S] assembly complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial [2Fe-2S] assembly complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial [2Fe-2S] assembly complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cysteine desulfurase

Names: NFS1 nitrogen fixation 1 homolog; cysteine desulfurase, mitochondrial; cysteine desulfurase, mitochondrial-like; nitrogen fixation gene 1

NP_445914.2

EC 2.8.1.7

XP_006235513.1

EC 2.8.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429576.1 → NP_001416505.1 cysteine desulfurase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

Q5FWU2
NM_053462.3 → NP_445914.2 cysteine desulfurase isoform 1

See identical proteins and their annotated locations for NP_445914.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

M0RAW3, Q3MHT2, Q5FWU2

Related

ENSRNOP00000066678.1, ENSRNOT00000072945.4

Conserved Domains (2) summary

PRK14012
Location:60 → 459

PRK14012; cysteine desulfurase; Provisional

pfam00266
Location:62 → 423

Aminotran_5; Aminotransferase class-V