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    Corin corin, serine peptidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289596, updated on 9-Dec-2024

    Summary

    Official Symbol
    Corinprovided by RGD
    Official Full Name
    corin, serine peptidaseprovided by RGD
    Primary source
    RGD:727887
    See related
    EnsemblRapid:ENSRNOG00000002302 AllianceGenome:RGD:727887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in regulation of blood pressure and regulation of renal sodium excretion. Located in cytoplasmic vesicle and plasma membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 408.1), Testes (RPKM 23.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Corin in Genome Data Viewer
    Location:
    14p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (36034613..36264671)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35680601..35910703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38247379..38474931)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit alpha 1 Neighboring gene nuclear transcription factor, X-box binding-like 1 Neighboring gene acidic leucine-rich nuclear phosphoprotein 32 family member A-like Neighboring gene synaptonemal complex central element protein 2-like Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene ATPase phospholipid transporting 10D (putative) Neighboring gene myosin light chain 6, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide hormone processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of renal sodium excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    atrial natriuretic peptide-converting enzyme
    Names
    pro-ANP-converting enzyme

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182473.2NP_872279.2  atrial natriuretic peptide-converting enzyme

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      D3ZN44, F1LS60, Q80YN4
      UniProtKB/TrEMBL
      A6JD74, J3QTE2
      Related
      ENSRNOP00000061602.2, ENSRNOT00000064128.5
      Conserved Domains (6) summary
      cd07445
      Location:200329
      CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd07888
      Location:521641
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd00112
      Location:372406
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:8671098
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:646680
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl02509
      Location:779859
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      36034613..36264671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770139.4XP_008768361.1  atrial natriuretic peptide-converting enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD87, A0A8I6AIB1
      Related
      ENSRNOP00000104752.1, ENSRNOT00000133364.1
      Conserved Domains (7) summary
      cd07445
      Location:134263
      CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd07888
      Location:455575
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      smart00020
      Location:8001029
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:306340
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:8011032
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:580614
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl02509
      Location:713793
      SRCR_2; Scavenger receptor cysteine-rich domain
    2. XM_063272920.1XP_063128990.1  atrial natriuretic peptide-converting enzyme isoform X3

    3. XM_039091707.2XP_038947635.1  atrial natriuretic peptide-converting enzyme isoform X2

      Conserved Domains (5) summary
      cd07888
      Location:210330
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd00112
      Location:6195
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:556787
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:335369
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl02509
      Location:468548
      SRCR_2; Scavenger receptor cysteine-rich domain
    4. XM_063272921.1XP_063128991.1  atrial natriuretic peptide-converting enzyme isoform X5

    5. XM_039091709.2XP_038947637.1  atrial natriuretic peptide-converting enzyme isoform X4

      Conserved Domains (5) summary
      cd07888
      Location:192312
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd00112
      Location:4377
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:538769
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:317351
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      cl02509
      Location:450530
      SRCR_2; Scavenger receptor cysteine-rich domain