U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Il20ra interleukin 20 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308716, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Il20raprovided by RGD
    Official Full Name
    interleukin 20 receptor subunit alphaprovided by RGD
    Primary source
    RGD:1307335
    See related
    EnsemblRapid:ENSRNOG00000012286 AllianceGenome:RGD:1307335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine receptor activity and interleukin-20 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway and regulation of bone resorption. Predicted to be active in plasma membrane. Orthologous to human IL20RA (interleukin 20 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 21.9), Adrenal (RPKM 21.0) and 4 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Il20ra in Genome Data Viewer
    Location:
    1p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16243683..16313229)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (14424215..14494226)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15180328..15222785)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482580 Neighboring gene interferon gamma receptor 1 Neighboring gene interleukin 22 receptor subunit alpha 2 Neighboring gene uncharacterized LOC120098799 Neighboring gene uncharacterized LOC120097186 Neighboring gene 60S ribosomal protein L27a-like Neighboring gene uncharacterized LOC134482581

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. Hsu YH, et al. PLoS One, 2013. PMID 23468852, Free PMC Article
    2. IL-19 is involved in the pathogenesis of endotoxic shock. Hsing CH, et al. Shock, 2008 Jan. PMID 18246602
    3. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. Hsu YH, et al. J Exp Med, 2011 Aug 29. PMID 21844205, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    interleukin-20 receptor subunit alpha
    Names
    interleukin 20 receptor alpha subunit
    interleukin 20 receptor, alpha

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107521.1 → NP_001100991.1  interleukin-20 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001100991.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473994
      UniProtKB/TrEMBL
      A6JPB5, D3ZJZ2
      Related
      ENSRNOP00000041938.3, ENSRNOT00000050656.4
      Conserved Domains (2) summary
      pfam01108
      Location:36 → 126
      Tissue_fac; Tissue factor
      pfam09294
      Location:138 → 241
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16243683..16313229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112779.2 → XP_038968707.1  interleukin-20 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      A6JPB5, D3ZJZ2
      Related
      ENSRNOP00000107560.1, ENSRNOT00000173644.1
      Conserved Domains (2) summary
      pfam01108
      Location:36 → 126
      Tissue_fac; Tissue factor
      pfam09294
      Location:138 → 241
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    2. XM_063262578.1 → XP_063118648.1  interleukin-20 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      A6JPB5, D3ZJZ2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous