Dcp1a decapping mRNA 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcp1aprovided by RGD
Official Full Name: decapping mRNA 1Aprovided by RGD
Primary source: RGD:1561298
See related: EnsemblRapid:ENSRNOG00000016015 AllianceGenome:RGD:1561298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561298
Summary: Enables kinesin binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA; deadenylation-independent decapping of nuclear-transcribed mRNA; and protein localization to cytoplasmic stress granule. Located in dendrite. Orthologous to human DCP1A (decapping mRNA 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 46.5), Adrenal (RPKM 44.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (5663437..5708623)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (5656960..5702151)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (6542415..6583856)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW530962 (e-PCR)
- UniSTS:244577

RH132389 (e-PCR)
- UniSTS:215672

BI276712 (e-PCR)
- UniSTS:260846

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA methylguanosine-cap decapping	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mRNA-decapping enzyme 1A

Names: test2

NP_001178760.2

EC 3.6.1.62

NP_001398681.1

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.