Impg1 interphotoreceptor matrix proteoglycan 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impg1provided by RGD
Official Full Name: interphotoreceptor matrix proteoglycan 1provided by RGD
Primary source: RGD:620499
See related: EnsemblRapid:ENSRNOG00000012479 AllianceGenome:RGD:620499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mlgapc
Summary: Predicted to enable chondroitin sulfate binding activity; heparin binding activity; and hyaluronic acid binding activity. Predicted to be involved in visual perception. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in interphotoreceptor matrix. Human ortholog(s) of this gene implicated in retinitis pigmentosa and vitelliform macular dystrophy. Orthologous to human IMPG1 (interphotoreceptor matrix proteoglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 8.8), Testes (RPKM 2.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (90123821..90269903, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (81243624..81389722, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (87733374..87879958, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Itga2 (e-PCR), detects polymorphism
- UniSTS:143609

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interphotoreceptor matrix	IEA Inferred from Electronic Annotation more info
located_in interphotoreceptor matrix	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interphotoreceptor matrix proteoglycan 1

Names: mucin-like glycoprotein associated with photoreceptor cells; sialoprotein associated with cones and rods

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023958.2 → NP_076448.2 interphotoreceptor matrix proteoglycan 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6ALU8, F1LQ01

Related

ENSRNOP00000017048.3, ENSRNOT00000017048.5

Conserved Domains (2) summary

pfam01390
Location:576 → 674

SEA; SEA domain

cl02507
Location:245 → 322

SEA; SEA domain