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    Prss53 serine protease 53 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss53provided by RGD
    Official Full Name
    serine protease 53provided by RGD
    Primary source
    RGD:1566127
    See related
    EnsemblRapid:ENSRNOG00000026040 AllianceGenome:RGD:1566127
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pol3s; RGD1311277; RGD1566127
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 45.2), Kidney (RPKM 37.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prss53 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191923398..191931292, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182494944..182501607, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199331108..199337129, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646 Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine protease 53
    Names
    polyserase-3
    protease, serine, 53
    NP_001102626.1
    XP_006230384.1
    XP_063127472.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109156.1NP_001102626.1  serine protease 53

      See identical proteins and their annotated locations for NP_001102626.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I9W0, D4AAD2
      Related
      ENSRNOP00000033673.5, ENSRNOT00000035672.7
      Conserved Domains (3) summary
      smart00020
      Location:45267
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:45271
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:302464
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191923398..191931292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271402.1XP_063127472.1  serine protease 53 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKU1, A6I9V9, D4AAD2
      Related
      ENSRNOP00000094565.1, ENSRNOT00000102265.2
    2. XM_006230322.5XP_006230384.1  serine protease 53 isoform X1

      See identical proteins and their annotated locations for XP_006230384.1

      UniProtKB/TrEMBL
      D4AAD2
      Related
      ENSRNOP00000102993.1, ENSRNOT00000157241.1
      Conserved Domains (1) summary
      cd00190
      Location:45310
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...