Slc1a6 solute carrier family 1 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc1a6provided by RGD
Official Full Name: solute carrier family 1 member 6provided by RGD
Primary source: RGD:620340
See related: EnsemblRapid:ENSRNOG00000007509 AllianceGenome:RGD:620340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EAAT4
Summary: Enables high-affinity L-glutamate transmembrane transporter activity and monoatomic anion transmembrane transporter activity. Involved in L-glutamate import across plasma membrane. Located in plasma membrane. Part of membrane protein complex. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Orthologous to human SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 56.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (11492422..11521007, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (10841836..10870424, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (13730101..13758170, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

strate-dependent gating of anion channels associated with excitatory amino acid transporter 4.
Title: Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4.
Data demonstrate that the neuronal glutamate transporter EAAT4 in Purkinje cells plays a critical role in the extrasynaptic diffusion of climbing fiber transmitters.
Title: Glutamate transporter EAAT4 in Purkinje cells controls intersynaptic diffusion of climbing fiber transmitter mediating inhibition of GABA release from interneurons.
EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3
Title: Hetero-oligomerization of neuronal glutamate transporters.
our findings of reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 reflect altered glial and neuronal properties and suggest reduced glutamate uptake in the cerebral cortex and the hippocampus of helpless animals
Title: Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression.
The Na+ coupled glutamate carrier EAAT4 is stimulated by PIKfyve, which thus mimics the stimulating effect of the serum and glucocorticoid inducible kinase SGK1.
Title: Regulation of the glutamate transporter EAAT4 by PIKfyve.
detailed expression of EAAT4 protein in different adult rat fore- and midbrain regions was examined
Title: High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain.
Ethanol dose- and time-dependently reduced EAAT4 activity.
Title: Inhibition of the activity of excitatory amino acid transporter 4 expressed in Xenopus oocytes after chronic exposure to ethanol.
Glutamate transporter EAAT4 is increased in hippocampal astrocytes following traumatic Brain Injury in rats.
Title: Glutamate transporter EAAT4 is increased in hippocampal astrocytes following lateral fluid-percussion injury in the rat.
The aspartate/glutamate transporter is localized in astrocytic processes around axonal or dendritic elements of glutamatergic axo-dendritic synaptic junctions in the frontoparietal somatosensory cortex.
Title: Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex.
These data suggest that PKC, possibly isozymes other than conventional ones, modulates the substrate-gated Cl(-) currents via rat EAAT4.
Title: Enhancement of substrate-gated Cl- currents via rat glutamate transporter EAAT4 by PMA.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc1a6 (e-PCR), detects polymorphism
- UniSTS:547017

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables acidic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in acidic amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in dicarboxylic acid transport	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter uptake	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of membrane protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: excitatory amino acid transporter 4

Names: high affinity aspartate/glutamate transporter; high-affinity neuronal glutamate transporter; sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032065.2 → NP_114454.2 excitatory amino acid transporter 4

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O35921, P97683

UniProtKB/TrEMBL

Q7TSX6

Related

ENSRNOP00000096116.1, ENSRNOT00000108905.2

Conserved Domains (1) summary

pfam00375
Location:55 → 519

SDF; Sodium:dicarboxylate symporter family