Entr1 endosome associated trafficking regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Entr1provided by RGD
Official Full Name: endosome associated trafficking regulator 1provided by RGD
Primary source: RGD:1305930
See related: EnsemblRapid:ENSRNOG00000018876 AllianceGenome:RGD:1305930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sdccag3
Summary: Predicted to be involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in endosome; microtubule organizing center; and midbody. Orthologous to human ENTR1 (endosome associated trafficking regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 411.0), Kidney (RPKM 271.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (29599059..29605780, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (9200967..9207688, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (3827498..3834219, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endosome-associated-trafficking regulator 1

Names: serologically defined colon cancer antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013135.2 → NP_001013153.2 endosome-associated-trafficking regulator 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTE3, F1LMK3

Related

ENSRNOP00000058381.3, ENSRNOT00000061669.6

Conserved Domains (2) summary

TIGR02168
Location:251 → 373

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

NF033928
Location:335 → 431

alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

29599059..29605780 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283534.1 → XP_063139604.1 endosome-associated-trafficking regulator 1 isoform X8
XM_006233681.5 → XP_006233743.1 endosome-associated-trafficking regulator 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A2U5, A6JTE3

Related

ENSRNOP00000084886.1, ENSRNOT00000105263.2

Conserved Domains (1) summary

cl23720
Location:228 → 335

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_039104801.2 → XP_038960729.1 endosome-associated-trafficking regulator 1 isoform X7
XM_006233682.5 → XP_006233744.1 endosome-associated-trafficking regulator 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AUN1

Related

ENSRNOP00000096122.1, ENSRNOT00000102669.2

Conserved Domains (1) summary

cl23720
Location:201 → 308

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_039104800.2 → XP_038960728.1 endosome-associated-trafficking regulator 1 isoform X6

Conserved Domains (2) summary

TIGR02168
Location:170 → 292

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

NF033928
Location:254 → 350

alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
XM_039104798.2 → XP_038960726.1 endosome-associated-trafficking regulator 1 isoform X3

Conserved Domains (2) summary

TIGR02168
Location:193 → 315

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

NF033928
Location:277 → 373

alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
XM_039104802.2 → XP_038960730.1 endosome-associated-trafficking regulator 1 isoform X10

UniProtKB/TrEMBL

A0A8I6ARC0
XM_006233685.5 → XP_006233747.1 endosome-associated-trafficking regulator 1 isoform X5

See identical proteins and their annotated locations for XP_006233747.1

UniProtKB/TrEMBL

A0A0G2JTN0

Related

ENSRNOP00000068774.2, ENSRNOT00000089705.3

Conserved Domains (1) summary

cl23720
Location:178 → 285

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_039104799.2 → XP_038960727.1 endosome-associated-trafficking regulator 1 isoform X4

Conserved Domains (2) summary

TIGR02168
Location:180 → 302

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

NF033928
Location:264 → 360

alph_xenorhab_A; alpha-xenorhabdolysin family binary toxin subunit A
XM_063283535.1 → XP_063139605.1 endosome-associated-trafficking regulator 1 isoform X9