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    Rp2 RP2 activator of ARL3 GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rp2provided by RGD
    Official Full Name
    RP2 activator of ARL3 GTPaseprovided by RGD
    Primary source
    RGD:1565124
    See related
    EnsemblRapid:ENSRNOG00000025428 AllianceGenome:RGD:1565124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rp2h; RGD1565124
    Summary
    Predicted to enable GTPase activator activity and magnesium ion binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; microtubule organizing center; and nuclear body. Predicted to be active in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 82.3), Lung (RPKM 76.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rp2 in Genome Data Viewer
    Location:
    Xq11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4426071..4470200, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1872582..1916704, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (2066298..2116661, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 1, pseudogene 1 Neighboring gene jade family PHD finger 3 Neighboring gene solute carrier family 25 member 39, pseudogene 2 Neighboring gene ribosomal protein L7, pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. X-linked retinitis pigmentosa: mutation spectrum of the RPGR and RP2 genes and correlation with visual function. Sharon D, et al. Invest Ophthalmol Vis Sci, 2000 Aug. PMID 10937588
    2. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Veltel S, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18376416
    3. The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Evans RJ, et al. Hum Mol Genet, 2010 Apr 1. PMID 20106869
    4. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Grayson C, et al. Hum Mol Genet, 2002 Nov 15. PMID 12417528
    5. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. Bartolini F, et al. J Biol Chem, 2002 Apr 26. PMID 11847227

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within post-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in post-chaperonin tubulin folding pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in periciliary membrane compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periciliary membrane compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein XRP2
    Names
    RP2, ARL3 GTPase activating protein
    retinitis pigmentosa 2 (X-linked recessive)
    retinitis pigmentosa 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109012.2 → NP_001102482.1  protein XRP2

      See identical proteins and their annotated locations for NP_001102482.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JZU1, A6JZU2, D3ZTJ0
      Related
      ENSRNOP00000051952.5, ENSRNOT00000055077.6
      Conserved Domains (2) summary
      smart00562
      Location:250 → 310
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      pfam07986
      Location:59 → 177
      TBCC; Tubulin binding cofactor C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      4426071..4470200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099932.2 → XP_038955860.1  protein XRP2 isoform X1

      UniProtKB/TrEMBL
      A6JZU1, A6JZU2, D3ZTJ0
      Conserved Domains (2) summary
      smart00562
      Location:250 → 310
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      pfam07986
      Location:59 → 177
      TBCC; Tubulin binding cofactor C
    Nucleotide Protein Strain
    Heading Accession and Version

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