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    Dennd6a DENN domain containing 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dennd6aprovided by RGD
    Official Full Name
    DENN domain containing 6Aprovided by RGD
    Primary source
    RGD:1306064
    See related
    EnsemblRapid:ENSRNOG00000011636 AllianceGenome:RGD:1306064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam116a; RGD1306064
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell-cell adhesion mediated by cadherin. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in recycling endosome. Orthologous to human DENND6A (DENN domain containing 6A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 185.4), Thymus (RPKM 167.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd6a in Genome Data Viewer
    Location:
    16p16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1843803..1892165)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1837019..1885420)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2278701..2327062)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene sarcolemma associated protein Neighboring gene small nucleolar RNA SNORA71 Neighboring gene ribosomal protein L34, pseudogene 9 Neighboring gene uncharacterized LOC134482439 Neighboring gene ARF GTPase 4 Neighboring gene phosphodiesterase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. Linford A, et al. Dev Cell, 2012 May 15. PMID 22595670, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein DENND6A
    Names
    DENN/MADD domain containing 6A
    family with sequence similarity 116, member A
    hypothetical protein MGC38041

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134467.1 → NP_001127939.1  protein DENND6A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A544
      Related
      ENSRNOP00000016233.5, ENSRNOT00000016233.7
      Conserved Domains (2) summary
      pfam08616
      Location:264 → 367
      SPA; Stabilization of polarity axis
      cl11519
      Location:168 → 353
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      1843803..1892165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094441.2 → XP_038950369.1  protein DENND6A isoform X1

      Related
      ENSRNOP00000107624.1, ENSRNOT00000142051.1
      Conserved Domains (3) summary
      cl11519
      Location:168 → 353
      DENN; DENN (AEX-3) domain
      cl40631
      Location:264 → 367
      SPA; Stabilization of polarity axis
      cl40632
      Location:61 → 198
      Avl9; Transport protein Avl9

    2. XM_017600075.2 → XP_017455564.1  protein DENND6A isoform X2

      Related
      ENSRNOP00000110826.1, ENSRNOT00000156954.1

    RNA

    1. XR_010058291.1 RNA Sequence

    2. XR_005494603.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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