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    Lmtk2 lemur tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmtk2provided by RGD
    Official Full Name
    lemur tyrosine kinase 2provided by RGD
    Primary source
    RGD:1598332
    See related
    EnsemblRapid:ENSRNOG00000025155 AllianceGenome:RGD:1598332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including endosomal transport; protein phosphorylation; and transferrin transport. Located in growth cone and neuronal cell body. Orthologous to human LMTK2 (lemur tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 215.9), Kidney (RPKM 206.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmtk2 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15540428..15622392, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10426772..10508750, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12409876..12546111, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene elongation factor 1-gamma-like Neighboring gene oncomodulin Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase. Wang H, et al. Mol Cell Proteomics, 2006 Nov. PMID 16887929
    2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. Wang H, et al. J Biol Chem, 2002 Dec 20. PMID 12393858
    3. Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment. Chibalina MV, et al. J Cell Sci, 2007 Dec 15. PMID 18029400, Free PMC Article
    4. Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase. Kesavapany S, et al. J Neurosci, 2003 Jun 15. PMID 12832520, Free PMC Article
    5. BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Inoue T, et al. Genes Cells, 2008 May. PMID 18429820

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin VI binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK2
    NP_001414165.1
    XP_038945281.1
    XP_038945282.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427236.1 → NP_001414165.1  serine/threonine-protein kinase LMTK2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1I1, D3ZBH5
      Related
      ENSRNOP00000050872.4, ENSRNOT00000046381.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15540428..15622392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089354.2 → XP_038945282.1  serine/threonine-protein kinase LMTK2 isoform X2

      UniProtKB/TrEMBL
      A6K1I1
      Related
      ENSRNOP00000083057.1, ENSRNOT00000092637.3
      Conserved Domains (2) summary
      PHA03247
      Location:1002 → 1381
      PHA03247; large tegument protein UL36; Provisional
      cd05086
      Location:137 → 407
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

    2. XM_039089353.2 → XP_038945281.1  serine/threonine-protein kinase LMTK2 isoform X1

      UniProtKB/TrEMBL
      A6K1I1
      Conserved Domains (2) summary
      PHA03247
      Location:1003 → 1382
      PHA03247; large tegument protein UL36; Provisional
      cd05086
      Location:138 → 408
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001137641.1: Suppressed sequence

      Description
      NM_001137641.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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