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    Zdhhc19 zinc finger DHHC-type palmitoyltransferase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc19provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 19provided by RGD
    Primary source
    RGD:1309014
    See related
    EnsemblRapid:ENSRNOG00000025055 AllianceGenome:RGD:1309014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560310
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of aggrephagy; and protein targeting to membrane. Predicted to be located in Golgi membrane and perinucleolar compartment. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 24.0), Heart (RPKM 12.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc19 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81782899..81794105, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68277847..68289110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71490346..71522959, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102547162 Neighboring gene uncharacterized LOC120095668 Neighboring gene solute carrier family 51 member A Neighboring gene uncharacterized LOC120095669 Neighboring gene phosphate cytidylyltransferase 1A, choline

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. Baumgart F, et al. Biochim Biophys Acta, 2010 Mar. PMID 20074548
    2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156468

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of aggrephagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinucleolar compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC19
    Names
    membrane-associated DHHC19 zinc finger protein
    probable palmitoyltransferase ZDHHC19
    zinc finger, DHHC domain containing 19
    zinc finger, DHHC-type containing 19
    NP_001034348.1
    XP_006248509.1
    XP_038944044.1
    XP_038944045.1
    XP_063126445.1
    XP_063126446.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039259.2 → NP_001034348.1  palmitoyltransferase ZDHHC19

      See identical proteins and their annotated locations for NP_001034348.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      Q2TGJ0
      Related
      ENSRNOP00000038846.4, ENSRNOT00000033026.8
      Conserved Domains (1) summary
      pfam01529
      Location:112 → 230
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81782899..81794105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248447.5 → XP_006248509.1  palmitoyltransferase ZDHHC19 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:110 → 228
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_063270376.1 → XP_063126446.1  palmitoyltransferase ZDHHC19 isoform X4

      UniProtKB/TrEMBL
      A6IRQ7

    3. XM_039088117.2 → XP_038944045.1  palmitoyltransferase ZDHHC19 isoform X4

      UniProtKB/TrEMBL
      A6IRQ7

    4. XM_039088116.2 → XP_038944044.1  palmitoyltransferase ZDHHC19 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:112 → 230
      DHHC; DHHC palmitoyltransferase

    5. XM_063270375.1 → XP_063126445.1  palmitoyltransferase ZDHHC19 isoform X3

    RNA

    1. XR_005491000.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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