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    Mcrip1 MAPK regulated co-repressor interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcrip1provided by RGD
    Official Full Name
    MAPK regulated co-repressor interacting protein 1provided by RGD
    Primary source
    RGD:1311925
    See related
    EnsemblRapid:ENSRNOG00000036691 AllianceGenome:RGD:1311925
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam195b; RGD1311925
    Summary
    Predicted to be involved in regulation of epithelial to mesenchymal transition. Predicted to be located in cytoplasmic stress granule and nucleus. Orthologous to human MCRIP1 (MAPK regulated corepressor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 71.4), Kidney (RPKM 67.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcrip1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106318985..106326442, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105820656..105828146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109720144..109727595, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC103693493 Neighboring gene glucagon receptor Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 like 1 Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. Ichikawa K, et al. Mol Cell, 2015 Apr 2. PMID 25728771
    2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mapk-regulated corepressor-interacting protein 1
    Names
    family with sequence similarity 195, member B
    protein FAM195B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108311.1 → NP_001101781.1  mapk-regulated corepressor-interacting protein 1

      See identical proteins and their annotated locations for NP_001101781.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/Swiss-Prot
      B0BN72
      Related
      ENSRNOP00000051843.4, ENSRNOT00000054960.5
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 93
      FAM195; FAM195 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106318985..106326442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269481.1 → XP_063125551.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    2. XM_017597414.3 → XP_017452903.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN72
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 93
      FAM195; FAM195 family

    3. XM_006247896.5 → XP_006247958.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006247958.1

      UniProtKB/Swiss-Prot
      B0BN72
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 93
      FAM195; FAM195 family

    4. XM_039086443.2 → XP_038942371.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN72
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 93
      FAM195; FAM195 family

    5. XM_017597415.3 → XP_017452904.1  mapk-regulated corepressor-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      pfam14799
      Location:1 → 88
      FAM195; FAM195 family

    6. XM_063269482.1 → XP_063125552.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    7. XM_063269480.1 → XP_063125550.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0BN72
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BN72.1 GenPept UniProtKB/Swiss-Prot:B0BN72

    Gene LinkOut

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