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    Tigar TP53 induced glycolysis regulatory phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502894, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tigarprovided by RGD
    Official Full Name
    TP53 induced glycolysis regulatory phosphataseprovided by RGD
    Primary source
    RGD:1560038
    See related
    EnsemblRapid:ENSRNOG00000051816 AllianceGenome:RGD:1560038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including cellular response to cobalt ion; positive regulation of phosphate metabolic process; and response to ischemia. Predicted to act upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Predicted to be located in cytosol; mitochondrial outer membrane; and nucleus. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 115.6), Adrenal (RPKM 104.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tigar in Genome Data Viewer
    Location:
    4q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161613306..161632248, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159927136..159946077, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159635145..159654108, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547991 Neighboring gene fibroblast growth factor 23 Neighboring gene cyclin D2 Neighboring gene uncharacterized LOC108350761

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cobalt ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of glucose catabolic process to lactate via pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intestinal epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pentose-phosphate shunt IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of response to DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-2,6-bisphosphatase TIGAR
    Names
    TP53-induced glycolysis and apoptosis regulator
    NP_001020235.1
    NP_001381980.1
    XP_038964186.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025064.2NP_001020235.1  fructose-2,6-bisphosphatase TIGAR isoform 2

      See identical proteins and their annotated locations for NP_001020235.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6A442, Q566D2
      Conserved Domains (1) summary
      cl11399
      Location:2151
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    2. NM_001395051.1NP_001381980.1  fructose-2,6-bisphosphatase TIGAR isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K8S8, A0A8I6AIY8, A6ILX2
      Related
      ENSRNOP00000074722.3, ENSRNOT00000091662.3
      Conserved Domains (1) summary
      pfam00300
      Location:6241
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      161613306..161632248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108258.2XP_038964186.1  fructose-2,6-bisphosphatase TIGAR isoform X1

      UniProtKB/TrEMBL
      A0A8I6A442, Q566D2
      Conserved Domains (1) summary
      cl11399
      Location:2151
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction