Abcb4 ATP binding cassette subfamily B member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb4provided by RGD
Official Full Name: ATP binding cassette subfamily B member 4provided by RGD
Primary source: RGD:620248
See related: AllianceGenome:RGD:620248
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mdr2; Pgy3
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in response to glucocorticoid and response to xenobiotic stimulus. Located in Golgi membrane and apical plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 347.0), Spleen (RPKM 133.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4q12

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (26106895..26164440, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (25150998..25209489, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (22133984..22192687, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hyperprolactinemia-induced changes in the mrp3 levels and their correlations with prolactin receptor expression were shown to differ in the kidney and liver cells.
Title: Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia.
Diabetes may enhance Mrp2 function and expression in liver, kidney and intestine.
Title: Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats.
These findings indicate that VEGF decreases P-glycoprotein activity via activation of flk-1 and Src, and suggest Src-mediated phosphorylation of caveolin-1 may play a role in downregulation of P-glycoprotein activity.
Title: Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.
Transcription of rat hepatic Mrp2 mRNA is initiated at multiple sites and contains potential upstream open reading frames (uORFs) in the 5' untranslated region (UTR) starting at -213, -149 and -109 nucleotides.
Title: Translational regulation of rat multidrug resistance-associated protein 2 expression is mediated by upstream open reading frames in the 5' untranslated region.
HAX-1 binds bile salt export protein (BSEP), cortactin, MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the apical membrane of cells.
Title: Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables ceramide floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine floppase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid secretion	IEA Inferred from Electronic Annotation more info
involved_in bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in bile acid secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to bile acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bile acid	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in ceramide translocation	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid translocation	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid translocation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid translocation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to fenofibrate	IEA Inferred from Electronic Annotation more info
involved_in response to fenofibrate	ISO Inferred from Sequence Orthology more info
involved_in response to fenofibrate	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
NOT involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylcholine translocator ABCB4

Names: ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette sub-family B member 4; ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2); ATP-binding cassette, subfamily B (MDR/TAP), member 4; P-glycoprotein 2; P-glycoprotein 3; P-glycoprotein 3/ multidrug resistance 2; multidrug resistance protein 2; multidrug resistance protein 3

NP_036822.1

EC 7.6.2.1

XP_006236061.1

EC 7.6.2.1

XP_008760919.1

EC 7.6.2.1

XP_017447963.1

EC 7.6.2.1

XP_038963003.1

EC 7.6.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012690.2 → NP_036822.1 phosphatidylcholine translocator ABCB4

See identical proteins and their annotated locations for NP_036822.1

Status: PROVISIONAL

Source sequence(s)

L15079

UniProtKB/Swiss-Prot

Q08201, Q78E07

UniProtKB/TrEMBL

A6K233, G3V9C8

Conserved Domains (3) summary

cd03249
Location:392 → 628

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:29 → 1271

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:58 → 342

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

26106895..26164440 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592474.3 → XP_017447963.1 phosphatidylcholine translocator ABCB4 isoform X3

UniProtKB/TrEMBL

A6K233, G3V9C8
XM_008762697.4 → XP_008760919.1 phosphatidylcholine translocator ABCB4 isoform X1

UniProtKB/TrEMBL

A6K233, G3V9C8

Conserved Domains (3) summary

cd03249
Location:392 → 628

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:29 → 1236

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:58 → 342

ABC_membrane; ABC transporter transmembrane region
XM_006235999.4 → XP_006236061.1 phosphatidylcholine translocator ABCB4 isoform X2

UniProtKB/TrEMBL

A6K233, G3V9C8

Conserved Domains (3) summary

cd03249
Location:325 → 561

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:76 → 1204

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:17 → 275

ABC_membrane; ABC transporter transmembrane region
XM_039107075.2 → XP_038963003.1 phosphatidylcholine translocator ABCB4 isoform X4

UniProtKB/TrEMBL

A6K233, G3V9C8

Conserved Domains (1) summary

PTZ00265
Location:37 → 1054

PTZ00265; multidrug resistance protein (mdr1); Provisional