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    Kpna2 karyopherin subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kpna2provided by RGD
    Official Full Name
    karyopherin subunit alpha 2provided by RGD
    Primary source
    RGD:621419
    See related
    EnsemblRapid:ENSRNOG00000015329 AllianceGenome:RGD:621419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    importin
    Summary
    Predicted to enable several functions, including histone deacetylase binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway and regulation of transcription by glucose. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in several cellular components, including glutamatergic synapse; nuclear membrane; and postsynaptic density. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1121.7), Thymus (RPKM 682.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kpna2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92433678..92445841, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91933951..91946115, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95200029..95212111, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene survival of motor neuron-related-splicing factor 30-like Neighboring gene uncharacterized LOC108352149 Neighboring gene transfer RNA arginine (anticodon CCG) 2 Neighboring gene similar to human chromosome 17 open reading frame 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats. Xu Z, et al. Cell Mol Neurobiol, 2016 Jul. PMID 26340948
    2. A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells. Cassany A, et al. Traffic, 2004 Jan. PMID 14675421
    3. Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation. Cai Y, et al. Dig Dis Sci, 2016 Mar. PMID 26526450
    4. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Guillemain G, et al. Biochem J, 2002 May 15. PMID 11988093, Free PMC Article
    5. The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Cattaruzzi G, et al. Nucleic Acids Res, 2007. PMID 17324944, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Karyopherin alpha2 co-localized well with active caspase-3 in neurons, indicating its potential role in neuronal apoptosis
      Title: Upregulated Expression of Karyopherin α2 is Involved in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.
    2. KPNA2-facilitated p65 nuclear translocation promotes NF-kappaB activation and inflammation in acute pancreatitis.
      Title: Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.
    3. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells
      Title: Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells.
    4. Data show that extracellular glucose regulates a nuclear transport pathway by increasing the nuclear efflux and shuttling of karyopherin alpha2 in cells in which glucose can stimulate the transcription of sugar-responsive genes.
      Title: A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108637

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynapse to nucleus signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by glucose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-1
    Names
    importin subunit alpha-2
    karyopherin (importin) alpha 2
    karyopherin alpha 2
    nuclear import protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270802.1 → NP_001257731.1  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_001257731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC089787, FM083931, FM115539
      UniProtKB/TrEMBL
      A6HK66, F7F4Z2, Q6P6T9, Q9Z0N9
      Related
      ENSRNOP00000020795.4, ENSRNOT00000020795.8
      Conserved Domains (3) summary
      COG5064
      Location:12 → 528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:457 → 494
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:288 → 320
      ARM; armadillo repeat [structural motif]

    2. NM_053483.2 → NP_445935.2  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_445935.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC089787, FM083931
      UniProtKB/TrEMBL
      A6HK66, F7F4Z2, Q6P6T9, Q9Z0N9
      Conserved Domains (3) summary
      COG5064
      Location:12 → 528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:457 → 494
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:288 → 320
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      92433678..92445841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270000.1 → XP_063126070.1  importin subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A6HK66, F7F4Z2, Q6P6T9, Q9Z0N9
    Nucleotide Protein Strain
    Heading Accession and Version

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