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    Madd MAP-kinase activating death domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maddprovided by RGD
    Official Full Name
    MAP-kinase activating death domainprovided by RGD
    Primary source
    RGD:619922
    See related
    EnsemblRapid:ENSRNOG00000012568 AllianceGenome:RGD:619922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RabGEF; RabGEP
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 155.6), Spleen (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Madd in Genome Data Viewer
    Location:
    3q24
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97570141..97613688, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77114330..77157865, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79960301..80003023, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101909 Neighboring gene Spi-1 proto-oncogene Neighboring gene myosin binding protein C3 Neighboring gene transfer RNA alanine (anticodon AGC) 34 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis--inhibition of interaction with GTP and reduction of this inhibition by phospholipid. Jin-no Y, et al. Genes Cells, 1997 Apr. PMID 9224661
    2. Purification and properties of Rab3 GEP (DENN/MADD). Sakisaka T, et al. Methods Enzymol, 2005. PMID 16473592
    3. The onset of apoptosis of neurons induced by ischemia-reperfusion injury is delayed by transient period of hypertension in rats. Smrcka M, et al. Physiol Res, 2003. PMID 12625816
    4. DENN, a novel human gene differentially expressed in normal and neoplastic cells. Chow VT, et al. DNA Seq, 1996. PMID 8988362
    5. Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins. Wada M, et al. J Biol Chem, 1997 Feb 14. PMID 9020086

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release.
      Title: MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of pancreatic amylase secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase-activating death domain protein
    Names
    Rab3 GDP/GTP exchange protein
    rab3 GDP/GTP exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429606.1 → NP_001416535.1  MAP kinase-activating death domain protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A7E5, A0A8L2Q8M9

    2. NM_001429607.1 → NP_001416536.1  MAP kinase-activating death domain protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZSL5, A0A8L2Q8M9

    3. NM_001429608.1 → NP_001416537.1  MAP kinase-activating death domain protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZTV3

    4. NM_001429609.1 → NP_001416538.1  MAP kinase-activating death domain protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2Q8M9

    5. NM_001429610.1 → NP_001416539.1  MAP kinase-activating death domain protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2Q8M9

    6. NM_001429611.1 → NP_001416540.1  MAP kinase-activating death domain protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZTV3

    7. NM_001429612.1 → NP_001416541.1  MAP kinase-activating death domain protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2Q8M9

    8. NM_001429613.1 → NP_001416542.1  MAP kinase-activating death domain protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2KA27, A0A8I5ZTV3

    9. NM_001429614.1 → NP_001416543.1  MAP kinase-activating death domain protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2Q8M9

    10. NM_053585.3 → NP_446037.1  MAP kinase-activating death domain protein isoform 1

      See identical proteins and their annotated locations for NP_446037.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O08873
      UniProtKB/TrEMBL
      A0A8L2Q8M9, A6HNA9
      Related
      ENSRNOP00000017360.5, ENSRNOT00000017360.8
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97570141..97613688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284778.1 → XP_063140848.1  MAP kinase-activating death domain protein isoform X32

    2. XM_063284754.1 → XP_063140824.1  MAP kinase-activating death domain protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    3. XM_063284759.1 → XP_063140829.1  MAP kinase-activating death domain protein isoform X7

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    4. XM_063284757.1 → XP_063140827.1  MAP kinase-activating death domain protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    5. XM_063284765.1 → XP_063140835.1  MAP kinase-activating death domain protein isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    6. XM_063284755.1 → XP_063140825.1  MAP kinase-activating death domain protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    7. XM_063284751.1 → XP_063140821.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    8. XM_063284764.1 → XP_063140834.1  MAP kinase-activating death domain protein isoform X12

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    9. XM_063284758.1 → XP_063140828.1  MAP kinase-activating death domain protein isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    10. XM_063284762.1 → XP_063140832.1  MAP kinase-activating death domain protein isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    11. XM_063284767.1 → XP_063140837.1  MAP kinase-activating death domain protein isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    12. XM_063284756.1 → XP_063140826.1  MAP kinase-activating death domain protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    13. XM_063284760.1 → XP_063140830.1  MAP kinase-activating death domain protein isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    14. XM_063284776.1 → XP_063140846.1  MAP kinase-activating death domain protein isoform X28

      UniProtKB/TrEMBL
      A0A8L2Q8M9
      Related
      ENSRNOP00000087537.2, ENSRNOT00000111515.2

    15. XM_063284772.1 → XP_063140842.1  MAP kinase-activating death domain protein isoform X24

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    16. XM_063284766.1 → XP_063140836.1  MAP kinase-activating death domain protein isoform X15

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    17. XM_063284771.1 → XP_063140841.1  MAP kinase-activating death domain protein isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    18. XM_039106011.2 → XP_038961939.1  MAP kinase-activating death domain protein isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZTV3
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    19. XM_063284763.1 → XP_063140833.1  MAP kinase-activating death domain protein isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    20. XM_039106022.2 → XP_038961950.1  MAP kinase-activating death domain protein isoform X22

      UniProtKB/TrEMBL
      A0A8L2Q8M9
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    21. XM_039106019.2 → XP_038961947.1  MAP kinase-activating death domain protein isoform X19

      UniProtKB/TrEMBL
      A0A8L2Q8M9
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    22. XM_039106028.2 → XP_038961956.1  MAP kinase-activating death domain protein isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZTV3
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    23. XM_039106021.2 → XP_038961949.1  MAP kinase-activating death domain protein isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTV3
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    24. XM_063284770.1 → XP_063140840.1  MAP kinase-activating death domain protein isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    25. XM_063284761.1 → XP_063140831.1  MAP kinase-activating death domain protein isoform X9

      Related
      ENSRNOP00000075233.2, ENSRNOT00000079394.3

    26. XM_039106031.2 → XP_038961959.1  MAP kinase-activating death domain protein isoform X31

      UniProtKB/TrEMBL
      A0A8L2Q8M9
      Conserved Domains (3) summary
      smart00801
      Location:485 → 553
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:172 → 401
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:7 → 97
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    27. XM_063284777.1 → XP_063140847.1  MAP kinase-activating death domain protein isoform X30

    28. XM_063284773.1 → XP_063140843.1  MAP kinase-activating death domain protein isoform X25

    29. XM_063284775.1 → XP_063140845.1  MAP kinase-activating death domain protein isoform X27

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    30. XM_063284793.1 → XP_063140863.1  MAP kinase-activating death domain protein isoform X47

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    31. XM_063284774.1 → XP_063140844.1  MAP kinase-activating death domain protein isoform X26

    32. XM_063284768.1 → XP_063140838.1  MAP kinase-activating death domain protein isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    33. XM_063284753.1 → XP_063140823.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    34. XM_063284752.1 → XP_063140822.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    35. XM_063284769.1 → XP_063140839.1  MAP kinase-activating death domain protein isoform X18

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    36. XM_063284792.1 → XP_063140862.1  MAP kinase-activating death domain protein isoform X46

    37. XM_063284781.1 → XP_063140851.1  MAP kinase-activating death domain protein isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    38. XM_063284780.1 → XP_063140850.1  MAP kinase-activating death domain protein isoform X34

      UniProtKB/TrEMBL
      A0A8I5Y5V9, A0A8I5ZTV3

    39. XM_063284787.1 → XP_063140857.1  MAP kinase-activating death domain protein isoform X41

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    40. XM_063284785.1 → XP_063140855.1  MAP kinase-activating death domain protein isoform X39

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    41. XM_063284786.1 → XP_063140856.1  MAP kinase-activating death domain protein isoform X40

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    42. XM_063284783.1 → XP_063140853.1  MAP kinase-activating death domain protein isoform X37

      UniProtKB/TrEMBL
      A0A8I5ZTV3

    43. XM_063284779.1 → XP_063140849.1  MAP kinase-activating death domain protein isoform X33

      UniProtKB/TrEMBL
      A0A8I5ZTV3
      Related
      ENSRNOP00000076460.2, ENSRNOT00000111613.2

    44. XM_063284790.1 → XP_063140860.1  MAP kinase-activating death domain protein isoform X44

    45. XM_063284789.1 → XP_063140859.1  MAP kinase-activating death domain protein isoform X43

      UniProtKB/TrEMBL
      A0A8L2Q8M9

    46. XM_063284788.1 → XP_063140858.1  MAP kinase-activating death domain protein isoform X42

    47. XM_063284784.1 → XP_063140854.1  MAP kinase-activating death domain protein isoform X38

    48. XM_063284782.1 → XP_063140852.1  MAP kinase-activating death domain protein isoform X36

    49. XM_063284791.1 → XP_063140861.1  MAP kinase-activating death domain protein isoform X45

      UniProtKB/TrEMBL
      A0A8L2Q8M9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08873.1 GenPept UniProtKB/Swiss-Prot:O08873

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