Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ikbkgprovided by RGD
Official Full Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by RGD
Primary source: RGD:735223
See related: EnsemblRapid:ENSRNOG00000060936 AllianceGenome:RGD:735223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nemo
Summary: Enables peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including anoikis; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within B cell homeostasis. Part of IkappaB kinase complex. Used to study irritable bowel syndrome and perinatal necrotizing enterocolitis. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 113.2), Thymus (RPKM 84.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157358279..157397563)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152216485..152241476)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156254187..156280046, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Damaged mitochondria recruit the effector NEMO to activate NF-kappaB signaling.
Title: Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling.
These results suggest that most NEMO molecules do not form a tripartite IKK complex with IKKalpha-IKKbeta heterodimer as previously reported in the literature but, instead, NEMO is able to form a complex with the monomeric forms of IKKalpha and IKKbeta.
Title: NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF069542 (e-PCR)
- UniSTS:163621

RH134438 (e-PCR)
- UniSTS:217718

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables linear polyubiquitin binding	ISO Inferred from Sequence Orthology more info
enables linear polyubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in anoikis	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IkappaB kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NF-kappa-B essential modulator

Names: I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; NF-kappa-B essential modifier; ikB kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa B kinase subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199103.2 → NP_954534.1 NF-kappa-B essential modulator

See identical proteins and their annotated locations for NP_954534.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6TMG5

UniProtKB/TrEMBL

A0A8L2RB98

Related

ENSRNOP00000075158.2, ENSRNOT00000078438.3

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:170 → 280

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:251 → 337

UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

157358279..157397563

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773603.4 → XP_008771825.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771825.1

UniProtKB/TrEMBL

A6KRP8

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773602.4 → XP_008771824.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771824.1

UniProtKB/TrEMBL

A6KRP8

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773601.4 → XP_008771823.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771823.1

UniProtKB/TrEMBL

A6KRP8

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_063279970.1 → XP_063136040.1 NF-kappa-B essential modulator isoform X3

UniProtKB/TrEMBL

A0A8L2RB98
XM_063279971.1 → XP_063136041.1 NF-kappa-B essential modulator isoform X4

UniProtKB/TrEMBL

A6KRP8

Related

ENSRNOP00000100028.1, ENSRNOT00000129825.1
XM_008773607.4 → XP_008771829.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771829.1

UniProtKB/TrEMBL

A6KRP8

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_006229580.5 → XP_006229642.1 NF-kappa-B essential modulator isoform X2

See identical proteins and their annotated locations for XP_006229642.1

UniProtKB/TrEMBL

A0A8I6AH74, A0A8L2RB98

Related

ENSRNOP00000110774.1, ENSRNOT00000122628.1

Conserved Domains (3) summary

cd09803
Location:269 → 355

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:188 → 298

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_063279972.1 → XP_063136042.1 NF-kappa-B essential modulator isoform X5

UniProtKB/TrEMBL

A6KRP8
XM_008773608.4 → XP_008771830.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771830.1

UniProtKB/TrEMBL

A6KRP8

Related

ENSRNOP00000092097.2, ENSRNOT00000107762.2

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_008773610.4 → XP_008771832.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771832.1

UniProtKB/TrEMBL

A6KRP8

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins