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    Mboat1 membrane bound O-acyltransferase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mboat1provided by RGD
    Official Full Name
    membrane bound O-acyltransferase domain containing 1provided by RGD
    Primary source
    RGD:1565561
    See related
    EnsemblRapid:ENSRNOG00000027125 AllianceGenome:RGD:1565561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565521; RGD1565561
    Summary
    Predicted to enable 1-acylglycerophosphoethanolamine O-acyltransferase activity and 1-acylglycerophosphoserine O-acyltransferase activity. Predicted to be involved in lipid modification; phospholipid metabolic process; and regulation of neuron projection development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human MBOAT1 (membrane bound O-acyltransferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 69.7), Kidney (RPKM 50.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mboat1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34540032..34653705, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (34331413..34445088, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (36061775..36177457, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene glycogenin 1, pseudogene 1 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 Neighboring gene angiotensin II receptor, type 1a Neighboring gene U2 spliceosomal RNA Neighboring gene non-POU domain containing, octamer-binding, pseudogene 6 Neighboring gene E2F transcription factor 3 Neighboring gene ribosomal protein L37-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189233

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphoserine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase 1
    NP_001102590.1
    XP_038951938.1
    XP_038951939.1
    XP_063132760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109120.1 → NP_001102590.1  lysophospholipid acyltransferase 1

      See identical proteins and their annotated locations for NP_001102590.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A6J7M5, F1LV18
      Related
      ENSRNOP00000034823.5, ENSRNOT00000036978.7
      Conserved Domains (1) summary
      cl00738
      Location:21 → 458
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      34540032..34653705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096010.2 → XP_038951938.1  lysophospholipid acyltransferase 1 isoform X1

      Related
      ENSRNOP00000098956.1, ENSRNOT00000153518.1
      Conserved Domains (1) summary
      cl00738
      Location:21 → 426
      MBOAT; membrane-bound O-acyltransferase family

    2. XM_039096011.2 → XP_038951939.1  lysophospholipid acyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cl00738
      Location:21 → 390
      MBOAT; membrane-bound O-acyltransferase family

    3. XM_063276690.1 → XP_063132760.1  lysophospholipid acyltransferase 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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