Cdc14a cell division cycle 14A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc14aprovided by RGD
Official Full Name: cell division cycle 14Aprovided by RGD
Primary source: RGD:1304649
See related: EnsemblRapid:ENSRNOG00000014515 AllianceGenome:RGD:1304649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: The protein encoded by this gene is a dual-specificity phosphatase that preferentially dephosphorylates cyclin dependent kinase substrates to regulate the cell cycle. In human cell lines, this protein localizes to interphase chromosomes, and depletion of the transcript results in centrosome separation and cytokinesis defects. In mouse, the protein localizes to the nucleus of prophase I arrested oocytes and then becomes dispersed in meiotically competent oocytes. Knockdown of the protein delays exit from metaphase I and results in eggs with chromosomal abnormalities and elevated aneuploidy, demonstrating a function in regulation of meiosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression: Biased expression in Spleen (RPKM 86.9), Lung (RPKM 86.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (206910475..207070537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (204225540..204380927, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (219302577..219458345, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:234810 (e-PCR)
- UniSTS:234810

Cdc14a (e-PCR), detects polymorphism
- UniSTS:506788

RH133205 (e-PCR)
- UniSTS:216488

D2Got140 (e-PCR)
- UniSTS:115390

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinociliary basal body	ISO Inferred from Sequence Orthology more info
located_in kinocilium	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium tip	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14A

Names: CDC14 cell division cycle 14 homolog A

NP_001101188.2

EC 3.1.3.16

EC 3.1.3.48

NP_001128328.1

EC 3.1.3.16

EC 3.1.3.48

XP_008759682.1

EC 3.1.3.16

EC 3.1.3.48

XP_017446421.1

EC 3.1.3.16

EC 3.1.3.48

XP_017446422.1

EC 3.1.3.16

EC 3.1.3.48

XP_063138006.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107718.2 → NP_001101188.2 dual specificity protein phosphatase CDC14A isoform 2

See identical proteins and their annotated locations for NP_001101188.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BC161876

UniProtKB/TrEMBL

A0A8I6B415, B1WBT1, D4ABH9

Conserved Domains (2) summary

cd14499
Location:163 → 336

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:10 → 154

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001134856.1 → NP_001128328.1 dual specificity protein phosphatase CDC14A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. It encodes isoform 1.

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZMT6, E9PSZ9

Related

ENSRNOP00000061448.2, ENSRNOT00000064735.6

Conserved Domains (3) summary

COG2453
Location:175 → 329

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

206910475..207070537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761460.4 → XP_008759682.1 dual specificity protein phosphatase CDC14A isoform X2

UniProtKB/TrEMBL

A0A8I5ZMT6

Related

ENSRNOP00000096339.2, ENSRNOT00000112422.2

Conserved Domains (3) summary

COG2453
Location:190 → 344

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 167

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:202 → 341

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_063281936.1 → XP_063138006.1 dual specificity protein phosphatase CDC14A isoform X3

UniProtKB/TrEMBL

A0A8I6B415
XM_017590932.3 → XP_017446421.1 dual specificity protein phosphatase CDC14A isoform X1

UniProtKB/TrEMBL

A0A8I6B415
XM_017590933.3 → XP_017446422.1 dual specificity protein phosphatase CDC14A isoform X3

UniProtKB/TrEMBL

A0A8I6B415