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    Arfgap2 ARF GTPase activating protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362162, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arfgap2provided by RGD
    Official Full Name
    ARF GTPase activating protein 2provided by RGD
    Primary source
    RGD:1306177
    See related
    EnsemblRapid:ENSRNOG00000014429 AllianceGenome:RGD:1306177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp289
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Orthologous to human ARFGAP2 (ARF GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 357.1), Muscle (RPKM 295.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfgap2 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97692105..97704246)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77236305..77248445)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80081541..80093659)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene acid phosphatase 2, lysosomal Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene uncharacterized LOC120101910 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. Weimer C, et al. J Cell Biol, 2008 Nov 17. PMID 19015319, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking
      Title: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124884

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 2
    Names
    ADP-ribosylation factor GTPase activating protein 2
    ARF GAP 2
    GTPase-activating protein ZNF289
    zinc finger protein 289

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033707.1 → NP_001028879.1  ADP-ribosylation factor GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_001028879.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101917
      UniProtKB/Swiss-Prot
      Q3MID3
      UniProtKB/TrEMBL
      A0A8I6A5U9, A6HNC3
      Related
      ENSRNOP00000053988.2, ENSRNOT00000057161.4
      Conserved Domains (2) summary
      PLN03114
      Location:12 → 470
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      cd09029
      Location:5 → 124
      ArfGap_ArfGap2; Arf1 GTPase-activating protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97692105..97704246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234530.5 → XP_006234592.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006234592.1

      UniProtKB/TrEMBL
      A0A8I6A5U9, A6HNC2
      Related
      ENSRNOP00000088256.1, ENSRNOT00000117465.2
      Conserved Domains (2) summary
      PLN03114
      Location:12 → 484
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      smart00105
      Location:14 → 117
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    2. XM_006234531.5 → XP_006234593.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5U9
      Conserved Domains (2) summary
      PLN03114
      Location:12 → 479
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      smart00105
      Location:14 → 117
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MID3.1 GenPept UniProtKB/Swiss-Prot:Q3MID3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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