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    Dmbt1 deleted in malignant brain tumors 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170568, updated on 9-Dec-2024

    Summary

    Symbol
    Dmbt1provided by RGD
    Full Name
    deleted in malignant brain tumors 1provided by RGD
    Primary source
    RGD:61984
    See related
    EnsemblRapid:ENSRNOG00000090509 AllianceGenome:RGD:61984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crpd; Dbmt1
    Summary
    Predicted to enable several functions, including heparan sulfate binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including response to biphenyl; response to estrogen; and tissue regeneration. Located in collagen-containing extracellular matrix. Biomarker of pheochromocytoma. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Uterus (RPKM 309.3), Spleen (RPKM 127.7) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dmbt1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (195047702..195126704)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185617469..185696476)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201620642..201689905) , (203149414..203228705)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A1 Neighboring gene uncharacterized LOC134485181 Neighboring gene HtrA serine peptidase 1 Neighboring gene similar to human chromosome 10 open reading frame 120 Neighboring gene deleted in malignant brain tumors 1 like 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparan sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoteichoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zymogen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zymogen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of columnar/cuboidal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to biphenyl IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in zymogen granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    scavenger receptor cysteine-rich domain-containing protein DMBT1
    Names
    crp-ductin
    deleted in malignant brain tumors 1 protein
    deleted in malignant brain tumors 1 protein-like
    ebnerin
    hensin
    pancrin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429894.1NP_001416823.1  scavenger receptor cysteine-rich domain-containing protein DMBT1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZZV0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      195047702..195126704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001428970.1: Suppressed sequence

      Description
      NM_001428970.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    2. NM_022849.3: Suppressed sequence

      Description
      NM_022849.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.