Mapk13 mitogen activated protein kinase 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk13provided by RGD
Official Full Name: mitogen activated protein kinase 13provided by RGD
Primary source: RGD:3045
See related: EnsemblRapid:ENSRNOG00000000515 AllianceGenome:RGD:3045
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prkm13
Summary: Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 272.5), Lung (RPKM 47.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (6836979..6847197)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (6835277..6845500)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (6018374..6027467)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Microtubular structure breakdown activated p38/MAPK pathway, accompanied with the upregulation of pVHL.
Title: Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
in pleural mesothelioma, p38 delta and C/EBP-alpha mediate proliferation and thus may represent new targets in mesothelioma therapy
Title: Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α.
regulates G1-S transition in hypoxic cardiac fibroblasts
Title: p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts.
Studies identify a novel regulatory pathway involving CITED2 and p38delta, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels.
Title: Physiological loading of joints prevents cartilage degradation through CITED2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to anisomycin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to anisomycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sorbitol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to sorbitol	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 13

Names: MAP kinase 13; MAP kinase p38 delta; MAPK 13; mitogen-activated protein kinase p38 delta; stress-activated protein kinase 4

NP_062104.3

EC 2.7.11.24

XP_038954553.1

EC 2.7.11.24

XP_063135153.1

EC 2.7.11.24

XP_063135154.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019231.3 → NP_062104.3 mitogen-activated protein kinase 13

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A6JJS2, G3V618, Q32Q45

Related

ENSRNOP00000000621.4, ENSRNOT00000000621.8

Conserved Domains (1) summary

cd07879
Location:9 → 351

STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

6836979..6847197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279083.1 → XP_063135153.1 mitogen-activated protein kinase 13 isoform X1

UniProtKB/TrEMBL

Q32Q45
XM_063279084.1 → XP_063135154.1 mitogen-activated protein kinase 13 isoform X3
XM_039098625.2 → XP_038954553.1 mitogen-activated protein kinase 13 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain