Hsbp1 heat shock factor binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsbp1provided by RGD
Official Full Name: heat shock factor binding protein 1provided by RGD
Primary source: RGD:628632
See related: EnsemblRapid:ENSRNOG00000014415 AllianceGenome:RGD:628632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsp25
Summary: Predicted to enable identical protein binding activity. Involved in muscle contraction. Predicted to be located in axon cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 915.5), Kidney (RPKM 819.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64309703..64314035)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (47401039..47405373)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (51985196..51989528)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression.
Title: HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression.
after diabetes, Protein kinase D control of LPL requires dissociation of Hsp25 from PKCdelta, association between PKCdelta and PKD, and vesicle fission.
Title: Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes.
The effect of spinal cord transection on HSP25 is muscle specific and time dependent.
Title: Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats.

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General gene information

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Markers

RH124761 (e-PCR)
- UniSTS:161583

RH127949 (e-PCR)
- UniSTS:211259

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular heat acclimation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock factor-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.