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    Tyk2 tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tyk2provided by RGD
    Official Full Name
    tyrosine kinase 2provided by RGD
    Primary source
    RGD:2320469
    See related
    EnsemblRapid:ENSRNOG00000032948 AllianceGenome:RGD:2320469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables type 1 angiotensin receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of lymphocyte proliferation; and positive regulation of type II interferon production. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 89.0), Thymus (RPKM 65.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tyk2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27918054..27943319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19641881..19667157, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22118224..22149807, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ferredoxin 2 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene uncharacterized LOC108351660 Neighboring gene cell division cycle 37, HSP90 cochaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2. Li H, et al. J Biol Chem, 2016 Jul 22. PMID 27235399, Free PMC Article
    2. Jak family of kinases in cancer. Verma A, et al. Cancer Metastasis Rev, 2003 Dec. PMID 12884916
    3. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Pan J, et al. Circ Res, 1997 Oct. PMID 9314843
    4. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Velazquez L, et al. Cell, 1992 Jul 24. PMID 1386289
    5. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Müller M, et al. Nature, 1993 Nov 11. PMID 8232552

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-23-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TYK2
    NP_001244276.1
    XP_006242647.1
    XP_006242648.1
    XP_038936573.1
    XP_038936574.1
    XP_063120777.1
    XP_063120778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257347.1 → NP_001244276.1  non-receptor tyrosine-protein kinase TYK2

      See identical proteins and their annotated locations for NP_001244276.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNP4, D3ZD03
      Related
      ENSRNOP00000104290.1, ENSRNOT00000130726.1
      Conserved Domains (6) summary
      cd05080
      Location:891 → 1173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:290 → 433
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:148 → 271
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:33 → 130
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:438 → 536
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:591 → 866
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27918054..27943319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242586.5 → XP_006242648.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      See identical proteins and their annotated locations for XP_006242648.1

      UniProtKB/TrEMBL
      A6JNP4, D3ZD03
      Related
      ENSRNOP00000107198.1, ENSRNOT00000168860.1
      Conserved Domains (6) summary
      cd05080
      Location:891 → 1173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:290 → 433
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:148 → 271
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:33 → 130
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:438 → 536
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:591 → 866
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006242585.5 → XP_006242647.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      See identical proteins and their annotated locations for XP_006242647.1

      UniProtKB/TrEMBL
      A6JNP4, D3ZD03
      Conserved Domains (6) summary
      cd05080
      Location:891 → 1173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:290 → 433
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:148 → 271
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:33 → 130
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:438 → 536
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:591 → 866
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063264707.1 → XP_063120777.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A6JNP4, D3ZD03

    4. XM_039080645.2 → XP_038936573.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      UniProtKB/TrEMBL
      A6JNP4, D3ZD03
      Related
      ENSRNOP00000048018.3, ENSRNOT00000041678.7
      Conserved Domains (6) summary
      cd05080
      Location:891 → 1173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:290 → 433
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:148 → 271
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:33 → 130
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:438 → 536
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:591 → 866
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063264708.1 → XP_063120778.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    6. XM_039080646.2 → XP_038936574.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      Conserved Domains (5) summary
      pfam17887
      Location:290 → 433
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:148 → 271
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:33 → 130
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:438 → 536
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:591 → 724
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001839127.3 RNA Sequence

    2. XR_010053913.1 RNA Sequence

    3. XR_005487735.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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