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    Eif4ebp3 eukaryotic translation initiation factor 4E binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100365872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4ebp3provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 3provided by RGD
    Primary source
    RGD:2324556
    See related
    AllianceGenome:RGD:2324556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Orthologous to several human genes including ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough) and ANKHD1 (ankyrin repeat and KH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 47.2), Thymus (RPKM 43.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4ebp3 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28540324..28542070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28263089..28268033)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29490981..29492727)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 9 Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene steroid receptor RNA activator 1 Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene solute carrier family 35, member A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202552.1 → NP_001189481.1  eukaryotic translation initiation factor 4E-binding protein 3

      See identical proteins and their annotated locations for NP_001189481.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J318, D4AEG8
      Conserved Domains (1) summary
      pfam05456
      Location:4 → 101
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28540324..28542070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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