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    Anks3 ankyrin repeat and sterile alpha motif domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anks3provided by RGD
    Official Full Name
    ankyrin repeat and sterile alpha motif domain containing 3provided by RGD
    Primary source
    RGD:1305833
    See related
    EnsemblRapid:ENSRNOG00000003186 AllianceGenome:RGD:1305833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305833
    Summary
    Predicted to be located in cytoplasm. Predicted to be active in cilium. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 77.6), Adrenal (RPKM 69.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anks3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11121504..11142261)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10614953..10635815)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10808780..10829507)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene mahogunin ring finger 1 Neighboring gene microRNA 3568

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. Delestré L, et al. PLoS One, 2015. PMID 26327442, Free PMC Article
    2. Anks3 alters the sub-cellular localization of the Nek7 kinase. Ramachandran H, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188091
    3. The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. Nakajima Y, et al. Kidney Int, 2018 May. PMID 29395339
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94228

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SAM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009676.2 → NP_001009676.1  ankyrin repeat and SAM domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001009676.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5M9H0
      UniProtKB/TrEMBL
      A0A0G2JX10
      Conserved Domains (5) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:422 → 481
      SAM; Sterile alpha motif
      cd00204
      Location:63 → 189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:106 → 199
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]

    2. NM_001414337.1 → NP_001401266.1  ankyrin repeat and SAM domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JX10, A6K4Q3
      Related
      ENSRNOP00000004298.5, ENSRNOT00000004298.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11121504..11142261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268896.1 → XP_063124966.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX10, A6K4Q3
      Related
      ENSRNOP00000109824.1, ENSRNOT00000135438.1

    2. XM_006245788.3 → XP_006245850.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX10
      Conserved Domains (5) summary
      cd09519
      Location:423 → 486
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:422 → 481
      SAM; Sterile alpha motif
      cd00204
      Location:63 → 189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:106 → 199
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:69 → 99
      ANK; ANK repeat [structural motif]

    3. XM_063268897.1 → XP_063124967.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JX10

    4. XM_039085842.2 → XP_038941770.2  ankyrin repeat and SAM domain-containing protein 3 isoform X5

    5. XM_008767484.4 → XP_008765706.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

      Conserved Domains (6) summary
      cd09519
      Location:294 → 357
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:293 → 352
      SAM; Sterile alpha motif
      cd00204
      Location:2 → 92
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11068
      Location:372 → 444
      YlqD; YlqD protein
      pfam13637
      Location:6 → 60
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:6 → 36
      ANK; ANK repeat [structural motif]

    6. XM_006245790.4 → XP_006245852.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006245852.1

      UniProtKB/TrEMBL
      A0A0G2JX10
      Conserved Domains (7) summary
      cd09519
      Location:386 → 449
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      smart00454
      Location:385 → 444
      SAM; Sterile alpha motif
      cd00204
      Location:26 → 152
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11068
      Location:464 → 536
      YlqD; YlqD protein
      pfam12796
      Location:69 → 162
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:18 → 72
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:32 → 62
      ANK; ANK repeat [structural motif]

    7. XM_039085843.2 → XP_038941771.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

      Conserved Domains (3) summary
      cd09519
      Location:260 → 323
      SAM_ANKS3; SAM domain of ANKS3 subfamily
      COG0666
      Location:6 → 65
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:5 → 36
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_005489787.2 RNA Sequence

    2. XR_005489786.2 RNA Sequence

    3. XR_005489788.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M9H0.1 GenPept UniProtKB/Swiss-Prot:Q5M9H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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