Plk4 polo-like kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plk4provided by RGD
Official Full Name: polo-like kinase 4provided by RGD
Primary source: RGD:1305390
See related: EnsemblRapid:ENSRNOG00000011654 AllianceGenome:RGD:1305390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including organelle assembly; positive regulation of centriole replication; and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including XY body; deuterosome; and microtubule organizing center. Predicted to be part of procentriole replication complex. Predicted to be active in nucleus. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 103.2), Testes (RPKM 90.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (125730480..125748894)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (123802527..123820942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (127686911..127705518)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway.
Title: NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
MicroRNA126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting pololike kinase 4.
Title: MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130777 (e-PCR)
- UniSTS:214061

Stk18 (e-PCR), detects polymorphism
- UniSTS:144519

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in centriole replication	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of centriole replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of centriole replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in trophoblast giant cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in trophoblast giant cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in XY body	IEA Inferred from Electronic Annotation more info
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in deuterosome	IEA Inferred from Electronic Annotation more info
located_in deuterosome	ISO Inferred from Sequence Orthology more info
located_in deuterosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in procentriole	IEA Inferred from Electronic Annotation more info
located_in procentriole	ISO Inferred from Sequence Orthology more info
part_of procentriole replication complex	IEA Inferred from Electronic Annotation more info
part_of procentriole replication complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK4

Names: PLK-4; serine/threonine-protein kinase Sak

NP_001382032.1

EC 2.7.11.21

XP_006232362.1

EC 2.7.11.21

XP_017446346.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395103.1 → NP_001382032.1 serine/threonine-protein kinase PLK4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

B2GUY1

UniProtKB/TrEMBL

A0A8L2Q8F8

Related

ENSRNOP00000016946.6, ENSRNOT00000016946.9

Conserved Domains (4) summary

cd13114
Location:547 → 658

POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13116
Location:838 → 917

POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd14186
Location:10 → 265

STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

pfam18409
Location:659 → 767

Plk4_PB2; Polo-like Kinase 4 Polo Box 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

125730480..125748894

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017590857.3 → XP_017446346.1 serine/threonine-protein kinase PLK4 isoform X1

UniProtKB/TrEMBL

A0A8I6A6C6, A6II36

Related

ENSRNOP00000086620.1, ENSRNOT00000095320.2
XM_006232300.3 → XP_006232362.1 serine/threonine-protein kinase PLK4 isoform X2

UniProtKB/TrEMBL

A0A0G2JZ86, A6II34

Conserved Domains (5) summary

smart00220
Location:5 → 218

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13114
Location:500 → 611

POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13115
Location:612 → 720

POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13116
Location:791 → 870

POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cl21453
Location:1 → 218

PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107669.1: Suppressed sequence

Description

NM_001107669.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.