Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk8ip1provided by RGD
Official Full Name: mitogen-activated protein kinase 8 interacting protein 1provided by RGD
Primary source: RGD:70937
See related: EnsemblRapid:ENSRNOG00000058478 AllianceGenome:RGD:70937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: JIP1; Jip-1; Mapk8ip
Summary: Enables MAP-kinase scaffold activity; identical protein binding activity; and protein kinase binding activity. Involved in negative regulation of JUN kinase activity and negative regulation of apoptotic process. Located in axonal growth cone; dendritic growth cone; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 500.0), Kidney (RPKM 189.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (98810540..98829302, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (78355051..78372946, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (81295023..81304181, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic beta-Cell Function.
Title: Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function.
HDAC-dependent regulatory circuit that promotes formation of JIP1:KIF5A:microtubule complexes that regulate intracellular transport of cargo such as autophagosomes, is reported.
Title: Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Suppression of IB1 level mimicked the harmful effects of palmitate on the beta cell survival and GSIS. Conversely, ectopic expression of IB1 counteracted the deleterious effects of palmitate on the beta cell survival and insulin secretion
Title: Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.
study found levels of JIP1 are not altered in Alzheimer's disease brains
Title: Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.
this study demonistrated that JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization
Title: JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization.
SOCS3 binds to the carboxyl terminus of C-Jun N-terminal kinase-interacting protein-1 (JIP1), increases its serine phosphorylation, and increases its binding to kinesin.
Title: Two cytokine signaling molecules co-operate to promote axonal transport and growth.
JIP1 and JIP3 play important roles in the activation of JNK during simulated ischemia-reperfusion challenge in H9c2 cells.
Title: Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion.
findings clarify the crosstalk between the two signaling modules, PSD-95 and JIP1 and the molecular mechanism underlying MLK3 activation in rat hippocampus after global ischemia
Title: Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia.
central role of the IB1/JIP-1 protein in the control of TRH-mediated TSH-beta stimulation.
Title: Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135410 (e-PCR)
- UniSTS:218687

BE118974 (e-PCR)
- UniSTS:248915

BF391846 (e-PCR)
- UniSTS:249837

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within JUN phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of CD8-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of CD8-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD8-positive, alpha-beta T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in dentate gyrus mossy fiber	IEA Inferred from Electronic Annotation more info
located_in dentate gyrus mossy fiber	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 1

Names: IB-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; islet-brain-1; mitogen activated protein kinase 8 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429682.1 → NP_001416611.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

B0VXR5, O88979, Q9R1H8, Q9R237, Q9WVI5, Q9WVI6

UniProtKB/TrEMBL

A0A8I6ABA5
NM_001429683.1 → NP_001416612.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6ABA5
NM_001429684.1 → NP_001416613.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNG8, A6HNH0
NM_053777.2 → NP_446229.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_446229.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6ABA5, A6HNG9

Related

ENSRNOP00000074684.1, ENSRNOT00000079746.3

Conserved Domains (2) summary

cd11943
Location:480 → 534

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

cd01212
Location:551 → 699

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

98810540..98829302 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104100.2 → XP_038960028.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform X2

Conserved Domains (3) summary

cd11943
Location:464 → 518

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

PHA03247
Location:161 → 332

PHA03247; large tegument protein UL36; Provisional

cd01212
Location:535 → 683

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
XM_039104102.2 → XP_038960030.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform X1

Related

ENSRNOP00000089891.1, ENSRNOT00000111802.2

Conserved Domains (3) summary

cd11943
Location:489 → 543

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

PHA03247
Location:186 → 357

PHA03247; large tegument protein UL36; Provisional

cd01212
Location:560 → 708

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
XM_039104101.2 → XP_038960029.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform X3

Conserved Domains (4) summary

cd11943
Location:455 → 509

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

PHA03247
Location:152 → 323

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:60 → 437

PHA03307; transcriptional regulator ICP4; Provisional

cd01212
Location:526 → 674

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain