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    Kcnd1 potassium voltage-gated channel subfamily D member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnd1provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily D member 1provided by RGD
    Primary source
    RGD:621364
    See related
    EnsemblRapid:ENSRNOG00000039544 AllianceGenome:RGD:621364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv4.1
    Summary
    Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 9.6), Uterus (RPKM 7.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnd1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17333612..17349255, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14661688..14678745, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15506724..15520712, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene OTU deubiquitinase 5 Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene GRIP1 associated protein 1 Neighboring gene transcription factor binding to IGHM enhancer 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation. Chiu CY, et al. Eur J Pain, 2022 Nov. PMID 36097791
    2. Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. Kim J, et al. J Physiol, 2005 Nov 15. PMID 16141270, Free PMC Article
    3. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J, et al. Neuroscience, 2010 Dec 15. PMID 20849929, Free PMC Article
    4. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). Isbrandt D, et al. Genomics, 2000 Mar 1. PMID 10729221
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.
      Title: K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables A-type (transient outward) potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily D member 1
    Names
    potassium channel, voltage gated Shal-related subfamily D, member 1
    potassium voltage gated channel Shal-related family member 1
    potassium voltage-gated channel, Shal-related subfamily, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105748.1 → NP_001099218.1  potassium voltage-gated channel subfamily D member 1 precursor

      See identical proteins and their annotated locations for NP_001099218.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474078
      UniProtKB/TrEMBL
      A6KP76, D3ZYK3
      Related
      ENSRNOP00000011994.1, ENSRNOT00000011994.5
      Conserved Domains (3) summary
      cl38908
      Location:6 → 143
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:185 → 417
      Ion_trans; Ion transport protein
      pfam11879
      Location:447 → 550
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17333612..17349255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099410.2 → XP_038955338.1  potassium voltage-gated channel subfamily D member 1 isoform X2

      Conserved Domains (2) summary
      pfam00520
      Location:3 → 154
      Ion_trans; Ion transport protein
      pfam11879
      Location:184 → 287
      DUF3399; Domain of unknown function (DUF3399)

    2. XM_039099409.2 → XP_038955337.1  potassium voltage-gated channel subfamily D member 1 isoform X1

      UniProtKB/TrEMBL
      A6KP76, D3ZYK3
      Conserved Domains (3) summary
      cl38908
      Location:6 → 143
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:185 → 417
      Ion_trans; Ion transport protein
      pfam11879
      Location:447 → 550
      DUF3399; Domain of unknown function (DUF3399)

    3. XM_063279755.1 → XP_063135825.1  potassium voltage-gated channel subfamily D member 1 isoform X1

      UniProtKB/TrEMBL
      A6KP76, D3ZYK3
    Nucleotide Protein Strain
    Heading Accession and Version

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