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    Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chchd3provided by RGD
    Official Full Name
    coiled-coil-helix-coiled-coil-helix domain containing 3provided by RGD
    Primary source
    RGD:1310325
    See related
    EnsemblRapid:ENSRNOG00000013211 AllianceGenome:RGD:1310325
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity and phosphatase binding activity. Predicted to be involved in cristae formation and mitochondrial fusion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1526.2), Heart (RPKM 1301.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chchd3 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (62327574..62584085, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (61360352..61616850, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (60080536..60358592, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486671 Neighboring gene elongin B, pseduogene 10 Neighboring gene high-mobility group box 1, pseudogene 5 Neighboring gene exocyst complex component 4 Neighboring gene FAD-linked sulfhydryl oxidase ALR-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional analysis of FLJ20420: a novel transcription factor for the BAG-1 promoter. Liu H, et al. PLoS One, 2012. PMID 22567091, Free PMC Article
    2. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, et al. Biol Chem, 2012 Nov. PMID 23109542
    3. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. Darshi M, et al. J Biol Chem, 2011 Jan 28. PMID 21081504, Free PMC Article
    4. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. Ott C, et al. PLoS One, 2015. PMID 25781180, Free PMC Article
    5. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner mitochondrial membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit MIC19
    Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106588.1 → NP_001100058.1  MICOS complex subunit MIC19

      See identical proteins and their annotated locations for NP_001100058.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A6IEK5, D3ZUX5
      Related
      ENSRNOP00000018001.6, ENSRNOT00000018001.6
      Conserved Domains (1) summary
      pfam05300
      Location:15 → 175
      DUF737; Protein of unknown function (DUF737)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      62327574..62584085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592526.3 → XP_017448015.1  MICOS complex subunit MIC19 isoform X2

      UniProtKB/TrEMBL
      D3ZUX5

    2. XM_017592525.3 → XP_017448014.1  MICOS complex subunit MIC19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD55, D3ZUX5
      Related
      ENSRNOP00000092148.1, ENSRNOT00000107634.2

    3. XM_039107283.2 → XP_038963211.1  MICOS complex subunit MIC19 isoform X3

      Conserved Domains (1) summary
      pfam05300
      Location:18 → 68
      DUF737; Protein of unknown function (DUF737)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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