U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    E2f4 E2F transcription factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360427, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    E2f4provided by RGD
    Official Full Name
    E2F transcription factor 4provided by RGD
    Primary source
    RGD:2322129
    See related
    EnsemblRapid:ENSRNOG00000015708 AllianceGenome:RGD:2322129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell volume homeostasis; cilium assembly; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human E2F4 (E2F transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 205.6), Thymus (RPKM 175.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See E2f4 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50084335..50091731)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33174396..33181806)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37252828..37260239)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3 Neighboring gene exocyst complex component 3-like 1 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 6318 Neighboring gene microRNA 328

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Humbert PO, et al. Mol Cell, 2000 Aug. PMID 10983976
    2. Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes. Dingar D, et al. J Mol Cell Cardiol, 2012 Dec. PMID 22985930
    3. Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Rempel RE, et al. Mol Cell, 2000 Aug. PMID 10983977
    4. In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1. Tommasi S, et al. J Biol Chem, 1999 Sep 24. PMID 10488129
    5. E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. Wang D, et al. Mol Cell Biol, 2000 May. PMID 10779331, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2F4 is part of a transcriptional repressor complex comprising p130 and HDAC1 in cardiac myocytes. Relief from E2F4-dependent gene silencing induces the expression of pro-apoptotic genes.
      Title: Anti-apoptotic function of the E2F transcription factor 4 (E2F4)/p130, a member of retinoblastoma gene family in cardiac myocytes.
    2. A control role for Id2 in hepatocyte priming, through a p130 dissociation-independent regulation of c-myc, in regenerating rat liver is reported.
      Title: Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration.
    3. E2F2, unlike E2F1, E2F3 and E2F5, does not induce apoptosis but even suppresses expression of several pro-apoptotic genes in primary cardiomyocytes; E2F1, E2F2, and E2F3 and E2F4 induce S-phase entry of primary cardiomyocytes
      Title: Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transcription factor E2F4
    Names
    E2F transcription factor 4, p107/p130-binding

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271345.1 → NP_001258274.1  transcription factor E2F4

      See identical proteins and their annotated locations for NP_001258274.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYN6, D4A9V4
      Related
      ENSRNOP00000021145.7, ENSRNOT00000021145.9
      Conserved Domains (2) summary
      cd14660
      Location:95 → 198
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:19 → 83
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50084335..50091731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255433.4 → XP_006255495.1  transcription factor E2F4 isoform X1

      UniProtKB/TrEMBL
      D4A9V4
      Conserved Domains (2) summary
      cd14660
      Location:95 → 198
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:19 → 83
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.