Lman2 lectin, mannose-binding 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lman2provided by RGD
Official Full Name: lectin, mannose-binding 2provided by RGD
Primary source: RGD:1308965
See related: EnsemblRapid:ENSRNOG00000016161 AllianceGenome:RGD:1308965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vip36
Summary: Predicted to enable D-mannose binding activity and heat shock protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of phagocytosis; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human LMAN2 (lectin, mannose binding 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 841.2), Kidney (RPKM 580.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9274362..9294950)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9269236..9286923)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9798136..9815820)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that actin filaments are involved in glycoprotein transport between the endoplasmic reticulum and cis-Golgi cisterna by using vesicular integral membrane protein-36 (VIP36).
Title: Clusters of VIP-36-positive vesicles between endoplasmic reticulum and Golgi apparatus in GH3 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144523 (e-PCR)
- UniSTS:233768

RH144631 (e-PCR)
- UniSTS:233876

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables D-mannose binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicular integral-membrane protein VIP36

Names: Vesicular integral-membrane protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115024.2 → NP_001108496.1 vesicular integral-membrane protein VIP36 precursor

See identical proteins and their annotated locations for NP_001108496.1

Status: PROVISIONAL

Source sequence(s)

BC158808

UniProtKB/TrEMBL

B0BNG3, F7FPK8

Related

ENSRNOP00000021638.6, ENSRNOT00000021638.9

Conserved Domains (1) summary

cd06901
Location:55 → 303

lectin_VIP36_VIPL; VIP36 and VIPL type 1 transmembrane proteins, lectin domain