Tslp thymic stromal lymphopoietin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tslpprovided by RGD
Official Full Name: thymic stromal lymphopoietinprovided by RGD
Primary source: RGD:1586479
See related: EnsemblRapid:ENSRNOG00000058856 AllianceGenome:RGD:1586479
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity and interleukin-7 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human TSLP (thymic stromal lymphopoietin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 8.2), Kidney (RPKM 8.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (24723990..24728419)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (24447409..24454244)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (25613601..25618066)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSLP in DRG neurons causes the development of neuropathic pain through T cells.
Title: TSLP in DRG neurons causes the development of neuropathic pain through T cells.
Increased Expression of Thymic Stromal Lymphopoietin in Chronic Constriction Injury of Rat Nerve.
Title: Increased Expression of Thymic Stromal Lymphopoietin in Chronic Constriction Injury of Rat Nerve.
A rat middle cerebral artery occlusion (MCAO) model was established, and it was demonstrated that the expression levels of TSLP and TSLPR were significantly increased in the infarct area between 12 and 72 h after MCAO.
Title: TSLP/TSLPR promote angiogenesis following ischemic stroke via activation of the PI3K/AKT pathway.
the application of TSLP short hairpin RNA caused a stark reversal of the TGF-beta1-induced cellular fibrosis.
Title: Treatment with cytokine thymic stromal lymphopoietin short hairpin RNA substantially reduces TGF-β1-induced interstitial cellular fibrosis.
We show that TSLP is expressed in the central nervous system and how the expression of TSLP at this site changes under pathological conditions
Title: Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system.
Angiotensin II-induced TSLP enhances Th17-driven immune response in atherosclerosis and hypertension.
Title: Angiotensin II induces TSLP via an AT1 receptor/NF-KappaB pathway, promoting Th17 differentiation.
During asthmatic period elevated TSLP expression was accompanied by Th2 type responses while vitamin A and corticosteroid both suppressed TSLP and Th2 factors expression.
Title: [The curative effect of inhaled vitamin A with corticosteroid on rat after asthmatic pneumonia and its influence on TSLP expression].
Respiratory syncytial virus can induce epithelial cells to produce TSLP.
Title: TSLP from RSV-stimulated rat airway epithelial cells activates myeloid dendritic cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables interleukin-7 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-7 receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-C motif) ligand 1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thymic stromal lymphopoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432547.1 → NP_001419476.1 thymic stromal lymphopoietin precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2JUJ3