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    Pklr pyruvate kinase L/R [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24651, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pklrprovided by RGD
    Official Full Name
    pyruvate kinase L/Rprovided by RGD
    Primary source
    RGD:3336
    See related
    EnsemblRapid:ENSRNOG00000020420 AllianceGenome:RGD:3336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PK1; PKL; Pklg
    Summary
    Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to insulin stimulus; and pyruvate metabolic process. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 407.7), Kidney (RPKM 72.2) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Pklr in Genome Data Viewer
    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176840779..176849637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174543008..174551863)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188449158..188458034)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 1 Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene CDC-like kinase 2 Neighboring gene microRNA 3541 Neighboring gene secretory carrier membrane protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables kinase activity  
    enables magnesium ion binding  
    enables monosaccharide binding PubMed 
    enables potassium ion binding  
    enables pyruvate kinase activity  
    enables pyruvate kinase activity PubMed 
    enables pyruvate kinase activity  
    enables pyruvate kinase activity  
    Process Evidence Code Pubs
    involved_in cellular response to epinephrine stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus PubMed 
    involved_in glycolytic process  
    involved_in glycolytic process PubMed 
    involved_in glycolytic process  
    involved_in glycolytic process  
    involved_in pyruvate biosynthetic process PubMed 
    involved_in response to ATP PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to glucose PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to metal ion PubMed 
    involved_in response to nutrient PubMed 
    acts_upstream_of_or_within response to other organism  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in plasma membrane  
    part_of pyruvate kinase complex  

    General protein information

    Preferred Names
    pyruvate kinase PKLR
    Names
    L-PK
    pyruvate kinase isozymes L/R
    pyruvate kinase isozymes R/L
    pyruvate kinase, liver and RBC
    pyruvate kinase, liver and red blood cell
    NP_036756.3
    XP_006232655.1
    XP_038957668.1
    XP_063137374.1
    XP_063137375.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012624.3NP_036756.3  pyruvate kinase PKLR

      See identical proteins and their annotated locations for NP_036756.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0H2UI07, B1WBN9
      Related
      ENSRNOP00000093132.1, ENSRNOT00000103387.2
      Conserved Domains (2) summary
      cd00288
      Location:54542
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:55539
      pyruv_kin; pyruvate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176840779..176849637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232593.5XP_006232655.1  pyruvate kinase PKLR isoform X1

      See identical proteins and their annotated locations for XP_006232655.1

      UniProtKB/Swiss-Prot
      P04763, P12928, Q64618
      UniProtKB/TrEMBL
      A0A0H2UI07, A6J6C1
      Related
      ENSRNOP00000027700.3, ENSRNOT00000027700.8
      Conserved Domains (1) summary
      cd00288
      Location:85573
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    2. XM_063281305.1XP_063137375.1  pyruvate kinase PKLR isoform X3

    3. XM_063281304.1XP_063137374.1  pyruvate kinase PKLR isoform X3

    4. XM_039101740.2XP_038957668.1  pyruvate kinase PKLR isoform X2

      UniProtKB/TrEMBL
      A0A0H2UI07
      Conserved Domains (1) summary
      cd00288
      Location:21509
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    RNA

    1. XR_005500240.2 RNA Sequence

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