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    Tmem259 transmembrane protein 259 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem259provided by RGD
    Official Full Name
    transmembrane protein 259provided by RGD
    Primary source
    RGD:1311136
    See related
    EnsemblRapid:ENSRNOG00000012808 AllianceGenome:RGD:1311136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mbrl; RGD1311136
    Summary
    Predicted to be involved in positive regulation of ERAD pathway and response to endoplasmic reticulum stress. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM259 (transmembrane protein 259). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 181.9), Heart (RPKM 157.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem259 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10374804..10381566)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9724196..9730932)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12771239..12777901, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene WD repeat domain 18 Neighboring gene AT-rich interaction domain 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The critical role of membralin in postnatal motor neuron survival and disease. Yang B, et al. Elife, 2015 May 15. PMID 25977983, Free PMC Article
    2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. Andersson O, et al. Brain Res Gene Expr Patterns, 2002 Oct. PMID 12638133
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genomic organization and expression (membralin)
      Title: Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membralin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100886.1 → NP_001094356.1  membralin

      Status: VALIDATED

      Source sequence(s)
      BC100259, CK843921
      UniProtKB/TrEMBL
      F1LPC5, Q498D7
      Related
      ENSRNOP00000017245.6, ENSRNOT00000017245.8
      Conserved Domains (2) summary
      pfam09746
      Location:34 → 393
      Membralin; tumor-associated protein
      cl41730
      Location:455 → 572
      KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10374804..10381566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078642.2 → XP_038934570.1  membralin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0I0
      Related
      ENSRNOP00000084057.1, ENSRNOT00000111728.2
      Conserved Domains (2) summary
      pfam09746
      Location:34 → 417
      Membralin; tumor-associated protein
      cl41730
      Location:479 → 596
      KLF9_13_N-like; Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins

    2. XM_006240869.5 → XP_006240931.1  membralin isoform X2

      UniProtKB/TrEMBL
      Q498D7
      Conserved Domains (1) summary
      pfam09746
      Location:34 → 376
      Membralin; Tumour-associated protein

    3. XM_006240870.5 → XP_006240932.1  membralin isoform X3

      UniProtKB/TrEMBL
      Q498D7
      Conserved Domains (1) summary
      pfam09746
      Location:34 → 365
      Membralin; Tumour-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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