Aloxe3 arachidonate epidermal lipoxygenase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aloxe3provided by RGD
Official Full Name: arachidonate epidermal lipoxygenase 3provided by RGD
Primary source: RGD:1306252
See related: EnsemblRapid:ENSRNOG00000007454 AllianceGenome:RGD:1306252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: eLOX-3; e-LOX-3
Summary: Predicted to enable hepoxilin A3 synthase activity; intramolecular hydroxytransferase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in arachidonate metabolic process; hepoxilin biosynthetic process; and sensory perception of pain. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate epidermal lipoxygenase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 30.9), Lung (RPKM 14.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54329224..54353167)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53830219..53854328)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55711996..55735915)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hepoxilin A3 synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hepoxilin A3 synthase activity	ISO Inferred from Sequence Orthology more info
enables hepoxilin A3 synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables hydroperoxy icosatetraenoate isomerase activity	IEA Inferred from Electronic Annotation more info
enables intramolecular hydroxytransferase activity	ISO Inferred from Sequence Orthology more info
enables intramolecular hydroxytransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
NOT enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepoxilin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hepoxilin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in lipoxygenase pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hydroperoxide isomerase ALOXE3

Names: arachidonate lipoxygenase 3; epidermal LOX-3; epidermis-type lipoxygenase 3; hydroperoxy dehydratase ALOXE3; hydroperoxy icosatetraenoate dehydratase; hydroperoxy icosatetraenoate isomerase

NP_001099263.1

EC 4.2.1.152

EC 5.4.4.7

XP_017452576.1

EC 4.2.1.152

EC 5.4.4.7

XP_017452577.1

EC 4.2.1.152

EC 5.4.4.7

XP_017452578.1

EC 4.2.1.152

EC 5.4.4.7

XP_038941369.1

EC 4.2.1.152

EC 5.4.4.7

XP_038941370.1

EC 4.2.1.152

EC 5.4.4.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105793.1 → NP_001099263.1 hydroperoxide isomerase ALOXE3

See identical proteins and their annotated locations for NP_001099263.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

D3ZKX9

Related

ENSRNOP00000010141.4, ENSRNOT00000010141.9

Conserved Domains (2) summary

cd01753
Location:2 → 116

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:268 → 690

Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54329224..54353167

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085442.2 → XP_038941370.1 hydroperoxide isomerase ALOXE3 isoform X4

Conserved Domains (1) summary

cd01753
Location:2 → 116

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
XM_039085441.2 → XP_038941369.1 hydroperoxide isomerase ALOXE3 isoform X3

Conserved Domains (2) summary

PLN02305
Location:268 → 468

PLN02305; lipoxygenase

cd01753
Location:2 → 116

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
XM_017597089.3 → XP_017452578.1 hydroperoxide isomerase ALOXE3 isoform X2

Related

ENSRNOP00000105835.1, ENSRNOT00000149702.1
XM_017597087.3 → XP_017452576.1 hydroperoxide isomerase ALOXE3 isoform X1

Related

ENSRNOP00000102822.1, ENSRNOT00000125878.1

Conserved Domains (2) summary

pfam00305
Location:230 → 652

Lipoxygenase; Lipoxygenase

cl00011
Location:12 → 78

PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
XM_017597088.3 → XP_017452577.1 hydroperoxide isomerase ALOXE3 isoform X1

Conserved Domains (2) summary

pfam00305
Location:230 → 652

Lipoxygenase; Lipoxygenase

cl00011
Location:12 → 78

PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...